Fig. 3

Scatter Plot of Associations of blood lipids on Risk of psychiatric disorders. Abbreviations: LDL-C, Low density lipoprotein cholesterol; HDL-C, High density lipoprotein cholesterol; TC, Total cholesterol; TG, Triglycerides; MR, Mendelian randomization; IVW, inverse-variance weighted MR; CI, confidence interval; OR, odds ratio; MDD, Major Depressive Disorder; PTSD, Post-Traumatic Stress Disorder; AD, Alzheimer’s Disease. The Scatterplot of independent instrument single-nucleotide polymorphism (SNP) exposure impacts vs. result effects from 2 independent samples augmented by the standard error of these effects on the vertical and horizontal sides (for presentation, alleles are coded so that all SNP exposure effects are positive). The solid lines denote the regression slopes fitted by the primary inverse variance–weighted (IVW) and complementary mendelian randomization (MR) approaches: slopes fitted by IVW MR method were very comparable in direction and magnitude to slopes fitted by MR-Egger and weighted median approaches for risk of the result