Fig. 1

The differentially expressed miRNAs and mRNAs in TM of POAG. A, C The miRNAs and mRNAs microarray expression profiling of controls and POAG patients in TM tissue is displayed by volcano map. The horizontal dotted lines and vertical dotted lines indicate limits for P values and fold change, respectively (|logFC|> 2 for miRNAs, or > 1 for mRNAs, and adjusted P < 0.05). B, D Data variability between control and POAG samples is displayed by PCA. E Heat map of the DEmiRNAs between controls and POAG patients in TM. Each small square represents the color depth corresponding to the expression value of the i-th row gene corresponding to the j-th column sample, which is converted by zscore. Red bars represent up-regulated DEmiRNAs, blue bars represent down-regulated DEmiRNAs. F GO annotation and KEGG pathway functional enrichment analyses of DEmRNAs by dotplot in TM for POAG