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Table 2 Newly updated Padua criteria for diagnosing ALVC

From: Arrhythmogenic left ventricular cardiomyopathy caused by a novel likely pathogenic DSP mutation, p.K1165Rfs*8, in a family with sudden cardiac death

Criteria Category

Major Criteria

Minor Criteria

Functional abnormality

 

• LV systolic dysfunction

• Regional LV Wall Hypokinesia or Akinesia

Structural myocardial abnormalities

• LV Subepicardial or Midmyocardial LGE

 

Electrocardiographic abnormalities

 

• Inverted T Waves in Precordial Leads V4-V6 (in absence of LBBB)

• Low QRS voltages

• RBBB Morphology Ventricular Arrhythmias

Familial Inheritance and Molecular Genetics

• Confirmed ACM in First-Degree Relative

• Identification of Pathogenic or Likely Pathogenetic ACM Mutation in Patient

• History of ACM in First-Degree Relative with Indeterminate Diagnostic Criteria

• Premature Sudden Death (< 35 years of age) Suspected to be Due to ACM in First-Degree Relative

• Pathological Confirmation or Diagnostic Criteria Confirmation of ACM in Second-Degree Relative

  1. LV Left ventricle, LGE Late gadolinium enhancement, LBBB Left bundle branch block, RBBB Right bundle branch block, ACM Arrhythmogenic cardiomyopathy