Fig. 2

Gene set enrichment analysis of subtypes. A. GSEA-based GO enrichment analysis in subtype I. The horizontal axis indicates the normalized enrichment score NES, and the color indicates the corrected P value. B. GSEA-based pathway enrichment analysis, where the upregulated pathways in subtype I are cell cycle, ubiquitin-mediated protein hydrolysis, herpes simplex virus type 1 infection, and oxytocin signaling pathway, and the downregulated pathways are viral carcinogenesis, coronavirus disease-COVID-19, and systemic lupus erythematosus. C. GSEA-based GO enrichment analysis in subtype II. D. GSEA-based pathway enrichment analysis, in which the pathways shown are all down-regulated pathways of subtype II. E. GSEA-based GO enrichment analysis in subtype III. F. GSEA-based pathway enrichment analysis, where the upregulated pathways in subtype III are Vibrio cholerae infection, pathogenic E. coli infection, NF-kappa B signaling pathway, ubiquitin-mediated protein hydrolysis, and rheumatoid arthritis, and the down-regulated pathways were cytokine-cytokine receptor interaction, proximal tubular bicarbonate reclamation, and neuroactive ligand-receptor interaction.