Table 2 Sensitivity analysis of primary and secondary MR analyses
From: The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study
Outcome | Number of IVs | R2 | F | Heterogeneity test | MR-Egger pleiotropy test | Steiger directionality test | MR-PRESSO Distortion Test | |||
|---|---|---|---|---|---|---|---|---|---|---|
Q | p-Value | Intercept | p-Value | Causal direction | p-Value | p-Value | ||||
Osteoarthritis | 430 | 2.5781% | 28.4632 | 600.5889 | 7.93 e-08 | 7.036 e-05 | 0.499 | TRUE | < 0.0001 | 0.922 |
Knee Osteoarthritis | 432 | 2.5754% | 24.6410 | 831.2233 | 1.06 e-27 | 3.798 e-03 | 0.053 | TRUE | < 0.0001 | 0.712 |
Hip Osteoarthritis | 425 | 2.5267% | 23.9976 | 727.6431 | 2.32 e-18 | 3.481 e-03 | 0.141 | TRUE | < 0.0001 | 0.446 |