Table 2 Mendelian randomization analysis for epigenetic aging on BMD
Exposure | Outcome | Method | nSNP | Beta | SE | P | OR |
|---|---|---|---|---|---|---|---|
GrimAge | FN-BMD | IVW | 4 | 0.022 | 0.021 | 0.297 | 1.023(0.980–1.067) |
GrimAge | FA-BMD | IVW | 4 | -0.026 | 0.045 | 0.569 | 0.975(0.893–1.064) |
GrimAge | LS-BMD | IVW | 4 | -0.036 | 0.025 | 0.151 | 0.965(0.919–1.013) |
HannumAge | FN-BMD | IVW | 9 | 0.002 | 0.015 | 0.915 | 1.002(0.973–1.031) |
HannumAge | FA-BMD | IVW | 9 | 0.028 | 0.025 | 0.259 | 1.029(0.979–1.081) |
HannumAge | LS-BMD | IVW | 8 | 0.008 | 0.021 | 0.681 | 1.008(0.969–1.050) |
HorvathAge | FN-BMD | IVW | 24 | -0.012 | 0.008 | 0.100 | 0.988(0.973–1.002) |
HorvathAge | FA-BMD | IVW | 24 | -0.009 | 0.017 | 0.579 | 0.991(0.958–1.024) |
HorvathAge | LS-BMD | IVW | 24 | -0.013 | 0.008 | 0.114 | 0.987(0.972–1.003) |
PhenoAge | FN-BMD | IVW | 11 | 0.007 | 0.008 | 0.401 | 1.007(0.991–1.023) |
PhenoAge | FA-BMD | IVW | 11 | 0.011 | 0.172 | 0.534 | 1.011(0.977–1.045) |
PhenoAge | LS-BMD | IVW | 11 | -0.001 | 0.010 | 0.926 | 0.999(0.980–1.018) |