Table 3 Mendelian randomization analysis for BMD on epigenetic aging
Exposure | Outcome | Method | nSNP | Beta | SE | P | OR |
|---|---|---|---|---|---|---|---|
FN-BMD | GrimAge | IVW | 15 | -0.079 | 0.143 | 0.582 | 0.924(0.699–1.223) |
FN-BMD | HannumAge | IVW | 20 | 0.172 | 0.125 | 0.169 | 1.188(0.929–1.519) |
FN-BMD | HorvathAge | IVW | 20 | 0.162 | 0.149 | 0.275 | 1.176(0.879–1.574) |
FN-BMD | PhenoAge | IVW | 20 | 0.427 | 0.181 | 0.019 | 1.532(1.074–2.186) |
FN-BMD | PhenoAge | MR Egger | 20 | -0.325 | 0.928 | 0.730 | 0.723(0.117–4.458) |
FA-BMD | GrimAge | IVW | 16 | -0.140 | 0.113 | 0.217 | 0.870(0.697–1.085) |
FA-BMD | HannumAge | IVW | 16 | -0.059 | 0.101 | 0.557 | 0.943(0.774–1.148) |
FA-BMD | HorvathAge | IVW | 16 | 0.108 | 0.093 | 0.248 | 1.114(0.928–1.337) |
FA-BMD | PhenoAge | IVW | 16 | 0.006 | 0.117 | 0.960 | 1.006(0.799–1.266) |
LS-BMD | GrimAge | IVW | 17 | -0.368 | 0.129 | 0.004 | 0.692(0.538–0.890) |
LS-BMD | HannumAge | IVW | 18 | -0.058 | 0.128 | 0.650 | 0.944(0.734–1.212) |
LS-BMD | HorvathAge | IVW | 22 | 0.088 | 0.132 | 0.503 | 1.092(0.844–1.415) |
LS-BMD | PhenoAge | IVW | 22 | -0.060 | 0.157 | 0.704 | 0.942(0.692–1.282) |