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Table 4 Heterogeneity and pleiotropic analysis for epigenetic aging and BMD after removing all the SNPs

From: Causal association of epigenetic aging and osteoporosis: a bidirectional Mendelian randomization study

Exposure

Outcome

Heterogeneity analysis

Pleiotropic test

Q

P value

intercept

P value

GrimAge

FN-BMD

2.881

0.410

-0.090

0.302

GrimAge

FA-BMD

2.279

0.517

0.076

0.634

GrimAge

LS-BMD

1.226

0.747

-0.070

0.454

HannumAge

FN-BMD

11.563

0.172

-0.001

0.944

HannumAge

FA-BMD

6.593

0.581

-0.008

0.755

HannumAge

LS-BMD

13.523

0.060

-0.006

0.774

HorvathAge

FN-BMD

27.523

0.234

-0.007

0.173

HorvathAge

FA-BMD

33.045

0.080

-0.004

0.754

HorvathAge

LS-BMD

19.754

0.657

-0.005

0.359

PhenoAge

FN-BMD

9.421

0.493

-0.001

0.873

PhenoAge

FA-BMD

5.041

0.888

0.017

0.369

PhenoAge

LS-BMD

5.029

0.889

-0.007

0.526

FN-BMD

GrimAge

9.735

0.781

0.063

0.185

FN-BMD

HannumAge

19.713

0.412

0.021

0.606

FN-BMD

HorvathAge

26.191

0.125

0.005

0.912

FN-BMD

PhenoAge

25.049

0.159

0.047

0.420

FA-BMD

GrimAge

22.460

0.096

0.008

0.816

FA-BMD

HannumAge

18.566

0.234

-0.015

0.618

FA-BMD

HorvathAge

10.340

0.798

-0.045

0.120

FA-BMD

PhenoAge

7.826

0.931

-0.018

0.606

LS-BMD

GrimAge

12.083

0.738

0.006

0.871

LS-BMD

HannumAge

17.953

0.392

-0.030

0.390

LS-BMD

HorvathAge

30.036

0.091

-0.020

0.625

LS-BMD

PhenoAge

27.207

0.164

-0.017

0.729