Fig. 1
From: A phenome-wide approach to identify causal risk factors for deep vein thrombosis
Overview of the study. First, a MR-PheWAS analysis to find risk factors for DVT was done using the MR-Base database and identified many of these to be associated with adiposity (N=24/57). This was followed by a two-sample mediation MR between BMI-associated pQTL data on DVT risk. MR = mendelian randomization; GWAS = genome-wide association study; VTE = venous thromboembolism; DVT = deep vein thrombosis; SNP = single-nucleotide polymorphism; pQTL = protein quantitative trait loci; PAI-1 = Plasminogen activator inhibitor-1; NOTCH1 = Neurogenic locus notch homolog protein 1; INHBC = Inhibin Subunit Beta C; S Table = Supplementary Table