Table 1 Traits passing the PhenoSpD significance threshold (5.43E-5) in the MR-PheWAS of all traits in UK Biobank on DVT risk with the Inverse Variance Weighted (SNP > 1) and Wald Ratio (SNP = 1). Exposures highlighted in orange are referred to as "adiposity-related" in the main text

Treatment/medication code: warfarin

7

IVW

4.29

3.09

5.49

0.61

1.40E-09

5.66E-40

0.4260

Mania/bipolar disorder/manic depression

1

WR

3.95

2.60

5.30

0.69

5.18E-06

NA

NA

Chronic obstructive airways disease/copd

1

WR

3.72

1.39

4.37

0.76

9.21E-07

NA

NA

Treatment/medication code: carbimazole

9

IVW

3.60

2.70

4.50

0.46

2.41E-12

5.21E-01

0.1048

Varicose veins

2

IVW

3.40

2.31

4.49

0.56

5.13E-07

4.42E-01

NA

Hyperthyroidism/thyrotoxicosis

6

IVW

2.39

1.88

2.90

0.26

8.69E-18

6.69E-01

0.3874

Varicose veins of lower extremities

16

IVW

1.90

1.30

2.50

0.31

2.36E-07

1.91E-01

0.5039

Lysine

1

WR

1.50

0.61

1.96

0.34

1.25E-05

NA

NA

Prospective memory result

2

IVW

1.46

1.02

1.90

0.23

5.33E-08

4.61E-01

NA

Long-standing illness disability or infirmity

14

IVW

1.25

0.87

1.63

0.20

8.13E-08

2.17E-01

0.4463

Taking other prescription medications

10

IVW

1.17

0.79

1.55

0.20

1.36E-06

4.83E-01

0.4399

Eicosapentaenoate (EPA; 20:5n3)

1

WR

1.10

0.75

1.45

0.18

3.14E-07

NA

NA

Stearidonate (18:4n3)

1

WR

1.09

0.73

1.45

0.18

1.22E-06

NA

NA

Docosapentaenoate (n3 DPA; 22:5n3)

1

WR

1.08

0.47

1.46

0.25

2.01E-05

NA

NA

Adrenate (22:4n6)

1

WR

1.01

0.55

1.32

0.20

3.48E-07

NA

NA

X-14473

1

WR

1.01

0.48

1.35

0.22

5.14E-06

NA

NA

Qualifications: None of the above

64

IVW

0.99

0.72

1.26

0.14

2.03E-10

6.18E-01

0.0335

Arachidonate (20:4n6)

1

WR

0.91

0.61

1.22

0.16

2.08E-06

NA

NA

Overall health rating

54

IVW

0.80

0.61

0.99

0.10

4.40E-14

5.14E-01

0.6398

Leg fat percentage (right)

246

IVW

0.59

0.47

0.71

0.06

3.32E-18

2.87E-03

0.2399

Comparative body size at age 10

157

IVW

0.57

0.46

0.68

0.06

3.98E-22

5.18E-01

0.1954

Arm fat percentage (right)

234

IVW

0.55

0.42

0.68

0.07

8.48E-14

8.47E-17

0.6940

Arm fat percentage (left)

253

IVW

0.55

0.41

0.68

0.07

1.61E-12

1.32E-24

0.6983

Leg fat percentage (left)

248

IVW

0.54

0.40

0.67

0.07

1.76E-12

7.00E-04

0.7261

Leg fat mass (right)

282

IVW

0.53

0.44

0.62

0.05

4.23E-28

9.07E-03

0.4978

Leg predicted mass (right)

361

IVW

0.52

0.43

0.60

0.04

8.79E-29

1.34E-02

0.6652

Leg predicted mass (left)

356

IVW

0.52

0.43

0.60

0.05

2.99E-27

5.18E-03

0.8052

Body fat percentage

253

IVW

0.51

0.41

0.61

0.05

1.48E-20

4.79E-02

0.6346

Leg fat-free mass (left)

361

IVW

0.51

0.42

0.60

0.05

6.10E-27

4.73E-03

0.8069

Leg fat-free mass (right)

363

IVW

0.50

0.41

0.59

0.05

1.11E-25

5.05E-03

0.5560

Waist circumference

227

IVW

0.50

0.40

0.59

0.05

1.74E-22

1.65E-02

0.5222

Leg fat mass (left)

281

IVW

0.50

0.40

0.59

0.05

1.85E-23

3.71E-02

0.5530

Weight

337

IVW

0.46

0.38

0.54

0.04

1.93E-28

1.33E-03

0.8573

Arm fat mass (right)

270

IVW

0.45

0.38

0.52

0.04

1.06E-30

3.60E-01

0.2818

Arm fat mass (left)

268

IVW

0.45

0.38

0.53

0.04

4.98E-29

1.93E-01

0.1348

Basal metabolic rate

377

IVW

0.45

0.36

0.54

0.05

2.62E-20

3.71E-03

0.7064

Arm predicted mass (left)

349

IVW

0.45

0.34

0.55

0.05

3.37E-14

1.53E-05

0.2577

Trunk fat percentage

237

IVW

0.44

0.35

0.54

0.05

2.91E-16

2.43E-03

0.6180

Whole body fat mass

280

IVW

0.44

0.36

0.51

0.04

4.65E-27

1.75E-01

0.1772

Arm fat-free mass (right)

350

IVW

0.44

0.33

0.54

0.05

1.66E-13

2.95E-04

0.2180

Arm predicted mass (right)

364

IVW

0.43

0.32

0.54

0.05

6.96E-13

9.35E-05

0.2660

Trunk fat mass

283

IVW

0.43

0.35

0.51

0.04

1.73E-23

2.90E-03

0.6360

Arm fat-free mass (left)

355

IVW

0.42

0.32

0.53

0.05

1.84E-12

3.14E-05

0.1920

Whole body water mass

405

IVW

0.42

0.32

0.51

0.05

7.67E-15

1.32E-04

0.3436

Whole body fat-free mass

405

IVW

0.41

0.31

0.50

0.05

3.90E-14

2.06E-04

0.3422

Body mass index (BMI)

305

IVW

0.40

0.32

0.47

0.04

1.60E-22

6.81E-02

0.5286

Trunk fat-free mass

406

IVW

0.39

0.29

0.48

0.05

2.32E-11

2.46E-06

0.0575

Trunk predicted mass

406

IVW

0.38

0.28

0.48

0.05

4.10E-11

9.09E-06

0.0513

Hip circumference

282

IVW

0.36

0.28

0.45

0.04

2.22E-13

2.92E-04

0.0876

Comparative height size at age 10

364

IVW

0.30

0.20

0.40

0.05

1.93E-06

1.56E-05

0.1080

Overweight

14

IVW

0.28

0.18

0.38

0.05

3.07E-05

3.44E-01

0.1711

Obesity class 1

17

IVW

0.18

0.11

0.25

0.03

1.34E-07

7.33E-01

0.2392

Standing height

591

IVW

0.17

0.09

0.24

0.04

4.61E-06

3.14E-05

0.1018

Obesity class 2

11

IVW

0.17

0.11

0.22

0.03

2.79E-06

5.45E-01

0.6859

Height

367

IVW

0.15

0.08

0.21

0.03

5.92E-06

1.58E-03

0.3372

Impedance of leg (right)

319

IVW

-0.55

-0.80

-0.35

0.12

2.21E-06

4.23E-06

0.0003

Impedance of leg (left)

323

IVW

-0.69

-1.05

-0.43

0.16

1.00E-05

9.96E-21

0.0072