Table 2 Reverse MR of traits passing the P-value threshold from the main analysis in Table 1. Exposures highlighted in orange are referred to as "adiposity-related" in the main text
From: A phenome-wide approach to identify causal risk factors for deep vein thrombosis
Outcome | No. SNP | MR method* | Beta* | SE | P-value | PHet (ML) | PPlt |
|---|---|---|---|---|---|---|---|
Treatment/medication code: warfarin | 9 | IVW | 0.29 | 0.02 | 3.81E-32 | 9.63E-02 | 5.11E-01 |
Stearidonate (18:4n3) | 5 | IVW | 1.35 | 0.50 | 6.78E-03 | 9.11E-01 | 8.41E-01 |
Leg predicted mass (left) | 9 | IVW | 0.51 | 0.23 | 2.73E-02 | 4.19E-04 | 6.13E-01 |
Leg fat-free mass (left) | 9 | IVW | 0.50 | 0.23 | 2.86E-02 | 5.20E-04 | 6.10E-01 |
Leg predicted mass (right) | 9 | IVW | 0.47 | 0.23 | 4.12E-02 | 3.95E-04 | 6.03E-01 |
Long-standing illness disability or infirmity | 9 | IVW | 0.19 | 0.10 | 4.69E-02 | 2.25E-01 | 9.50E-01 |
Leg fat-free mass (right) | 9 | IVW | 0.47 | 0.23 | 4.71E-02 | 3.47E-04 | 6.09E-01 |
Taking other prescription medications | 9 | IVW | 0.16 | 0.10 | 8.84E-02 | 7.97E-01 | 2.34E-01 |
Varicose veins | 9 | IVW | 0.02 | 0.01 | 9.89E-02 | 7.21E-01 | 3.19E-01 |
Eicosapentaenoate (EPA; 20:5n3) | 5 | IVW | 0.58 | 0.44 | 1.87E-01 | 5.75E-01 | 8.16E-01 |
Leg fat percentage (left) | 9 | IVW | -0.35 | 0.27 | 1.91E-01 | 8.77E-07 | 9.80E-01 |
Qualifications: None of the above | 9 | IVW | -0.11 | 0.09 | 2.06E-01 | 1.02E-01 | 8.73E-01 |
Varicose veins of lower extremities | 9 | IVW | 0.04 | 0.03 | 2.38E-01 | 2.08E-01 | 5.93E-01 |
Weight | 9 | IVW | 0.22 | 0.25 | 3.62E-01 | 1.95E-02 | 5.78E-01 |
Leg fat percentage (right) | 9 | IVW | -0.25 | 0.28 | 3.80E-01 | 3.18E-07 | 9.90E-01 |
Hyperthyroidism/thyrotoxicosis | 9 | IVW | -0.01 | 0.02 | 3.89E-01 | 9.48E-01 | 6.27E-01 |
Arm fat percentage (left) | 9 | IVW | 0.35 | 0.42 | 3.96E-01 | 6.65E-12 | 8.82E-01 |
Arm fat percentage (right) | 9 | IVW | 0.34 | 0.41 | 4.15E-01 | 1.70E-11 | 8.55E-01 |
Arm fat mass (left) | 9 | IVW | 0.31 | 0.39 | 4.21E-01 | 1.84E-05 | 7.77E-01 |
Arachidonate (20:4n6) | 5 | IVW | 0.24 | 0.30 | 4.28E-01 | 8.53E-01 | 8.94E-01 |
Hip circumference | 9 | IVW | 0.22 | 0.29 | 4.37E-01 | 8.58E-03 | 9.32E-01 |
Basal metabolic rate | 9 | IVW | 0.21 | 0.28 | 4.54E-01 | 1.46E-06 | 6.68E-01 |
Whole body water mass | 9 | IVW | 0.20 | 0.32 | 5.31E-01 | 1.38E-09 | 7.29E-01 |
Whole body fat-free mass | 9 | IVW | 0.20 | 0.32 | 5.42E-01 | 1.22E-09 | 7.16E-01 |
Waist circumference | 9 | IVW | 0.12 | 0.25 | 6.24E-01 | 1.70E-02 | 9.81E-01 |
Obesity class 2 | 5 | IVW | 1.20 | 2.53 | 6.33E-01 | 7.08E-01 | 5.15E-01 |
Arm predicted mass (right) | 9 | IVW | -0.13 | 0.32 | 6.91E-01 | 1.30E-10 | 8.85E-01 |
Overweight | 5 | IVW | -0.46 | 1.17 | 6.95E-01 | 6.26E-01 | 8.70E-01 |
Trunk fat percentage | 9 | IVW | 0.18 | 0.45 | 6.98E-01 | 3.16E-09 | 9.39E-01 |
Whole body fat mass | 9 | IVW | 0.13 | 0.36 | 7.18E-01 | 1.43E-04 | 6.77E-01 |
Arm fat-free mass (right) | 9 | IVW | -0.11 | 0.33 | 7.30E-01 | 9.99E-11 | 7.45E-01 |
Arm predicted mass (left) | 9 | IVW | -0.11 | 0.33 | 7.47E-01 | 1.21E-10 | 8.46E-01 |
Comparative height size at age 10 | 9 | IVW | 0.07 | 0.25 | 7.70E-01 | 2.37E-04 | 6.67E-01 |
Treatment/medication code: carbimazole | 9 | IVW | 0.00 | 0.01 | 7.83E-01 | 3.46E-01 | 9.43E-01 |
Arm fat-free mass (left) | 9 | IVW | -0.09 | 0.32 | 7.92E-01 | 5.50E-10 | 8.24E-01 |
Mania/bipolar/manic depression | 9 | IVW | 0.00 | 0.01 | 8.09E-01 | 4.14E-01 | 8.69E-01 |
Trunk predicted mass | 9 | IVW | 0.07 | 0.39 | 8.67E-01 | 1.33E-15 | 7.36E-01 |
Leg fat mass (right) | 9 | IVW | -0.04 | 0.29 | 8.84E-01 | 1.75E-04 | 8.88E-01 |
Trunk fat-free mass | 9 | IVW | 0.05 | 0.39 | 9.03E-01 | 1.59E-15 | 7.25E-01 |
Body fat percentage | 9 | IVW | 0.04 | 0.37 | 9.06E-01 | 5.73E-09 | 8.91E-01 |