Table 3 Mediation MR analysis of BMI-associated protein levels on DVT passing the multiple testing P-value threshold (0.003), with a two-step MR of the indirect effect of BMI on DVT through protein levels and proportion mediated (%) by PAI-1
From: A phenome-wide approach to identify causal risk factors for deep vein thrombosis
Exposure | MR method | Log Risk Ratio* | CI (95%) | P-value | Beta coefficient—BMI to protein* | Proportion (%) mediated by protein | |
|---|---|---|---|---|---|---|---|
Neurogenic locus notch homolog protein 1 | Wald ratio | 0.57 | 0.45 | 0.68 | 1.12E-23 | -0.15 | Effect not consistent |
Plasminogen activator inhibitor 1 | Wald ratio | 0.42 | 0.30 | 0.54 | 4.27E-12 | 0.17 | 18.56 |
Inhibin beta C chain | Wald ratio | -1.18 | -2.18 | -0.69 | 1.96E-03 | 0.45 | Effect not consistent |