Fig. 2

The differentially expressed proteins (DEPs) screening and annotation enrichment analysis. (A) Volcano map of DEGs, a total of 115 DEPs were screened out, including 110 up-regulated proteins and 5 down-regulated proteins. The red represents up-regulated differential genes, green represents down-regulated differential genes and black represents no significant difference genes. (B-D) Gene Ontology (GO) enrichment analyses of DEGs, including biological process (BP), cellular component (CC), and molecular function (MF), respectively. The y-axis represents different GO terms, the x-axis represents gene ratio enriched in relative GO terms, the circle size refers to gene numbers, and the color represents -log10 (p-value). (E) Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of DEGs, the Fig shows the top 20 enriched pathways. (F) Disease Ontology (DO) enrichment analysis was performed on DEGs and the top 20 terms were selected for visualization