Polygenic risk for triglyceride levels in the presence of a high impact rare variant

BMC Medical Genomics

Table 1 Lipid and other phenotypic/clinical variables, and sex effects, in adults with a 22q11.2 microdeletion

*Continuous variables*
	Total sample			Males			Females
	n	Mean	SD	n	Mean	SD	n	Mean	SD
Lipid levels
TG (mmol/L)^a	149	1.92	1.18	74	2.25	1.37	75	1.60	0.85
HDLC (mmol/L)	150	1.15	0.35	75	0.99	0.28	75	1.31	0.33
LDLC (mmol/L)	148	2.71	0.87	73	2.67	0.86	75	2.75	0.88
LDLC statin-adjusted (mmol/L)^b	148	2.81	0.93	73	2.74	0.85	75	2.88	0.99
TC (mmol/L)	151	4.72	0.98	76	4.64	0.98	75	4.80	0.99
TC statin-adjusted (mmol/L)^b	151	4.84	1.06	76	4.74	1.02	75	4.94	1.09
Other clinical/demographic variables
BMI (kg/m²)	151	30.29	7.39	76	29.82	7.36	75	30.77	7.44
Age^c	151	35.66	11.2	76	34.92	11.51	75	36.42	10.9
*Categorical variables*
	Total sample (n = 151)			Males (n = 76)			Females (n = 75)
	n		%	n		%	n		%
Mild-moderate HTG^a,d	67		45.0	45		60.8	22		29.3
Other clinical/demographic variables
On statin medication	16		10.6	7		9.2	9		12.0
Type 2 diabetes	14		9.3	8		10.5	6		8.0
Psychotic illness^e	65		43.0	37		48.7	28		37.3
European ancestry	135		89.4	71		93.4	64		85.3

SD Standard deviation, TG Triglyceride, LDLC Low density lipoprotein cholesterol, HDLC High density lipoprotein cholesterol, TC Total cholesterol, BMI Body mass index, HTG Hypertriglyceridemia, T2D type 2 diabetes
^aExcluded one individual on fibrates (n = 1)
^bFor individuals on statin medications, LDLC and TC levels were divided by 0.7 and 0.8, respectively, as in previous studies [8, 9, 32]
^cRecorded at the date of TC measurement to the nearest 0.1 years
^dMild-moderate HTG is defined as having a TG level between 1.7–10 mmol/L. For this row only, there are n = 74 males and n = 149 total
^eDefined as schizophrenia or schizoaffective disorder

ISSN: 1755-8794