Fig. 2

Basic FA expression and mutation characteristics in patients with MDS/AML. A total of 4259 cases from 10 cohorts were included in the study (a). The bar graph of each cohort was displayed using the “ggbarplot” R package. The proportion of MDS and AML was represented in a hollow pie chart using the “ggplot2” and “ggforce” R packages. The “plotrix” R package was used to visualize the proportion of AML and MDS patients in different groups of cohorts (b), gender, and race (c). In contrast, a “plotrix “R package was for the cytogenetic risk (d) and FAB (e) of AML patients. The mutation number and percentage of FA pathway genes in AML and MDS patients were analyzed, and the results were visualized using a “ggplot2” R package (f). We showed the mutation rates of FLT3, FA, CEBPA, IDH1, NPM1 (g), and FA pathway genes (h) in AML and MDS patients through radar diagrams created with the “fmsb” R package