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Fig. 6 | BMC Medical Genomics

Fig. 6

From: Mutation spectrum, expression profiling, and prognosis evaluation of Fanconi anemia signaling pathway genes for 4259 patients with myelodysplastic syndromes or acute myeloid leukemia

Fig. 6

Relationship between FA gene expression and TMB. Firstly, we employed the Wilcox test to analyze the TMB of AML and MDS patients, and the results were displayed using the “ggbarpAlot” function (a-b). We also used the cor.test to examine the Spearman correlation between the gene expression values of FA pathways and TMB. To visually represent the correlation between TMB and the expression of each FA gene, we created a radar diagram using the “fmsb” R package (c). Furthermore, a heat map was generated using the “Corrplot” R package to display the relationships among genes (d). To provide a network visualization in the form of a tree layout, we utilized the “iGraph” R package (e). Finally, scatter plots illustrating the correlation between TMB and the expression of hub genes within the network, namely BRIP1, FANCE, ERCC4, and MAD2L2, were created using the “ggplot2” R package (f)

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BMC Medical Genomics

ISSN: 1755-8794

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