Table 3 Logistic regression analysis of the association between MMP3, MMP14 and MMP25 polymorphism with susceptibility of ischemic or hemorrhagic stroke

rs520540

Allele

A

586 (48.1%)

454 (37.2%)

0.64 (0.07, 0.85)

< 0.001*

52 (40.6%)

47 (36.7%)

1.18 (0.79, 1.56)

0.522

G

632 (51.9%)

766 (62.8%)

1.00

76 (59.4%)

81 (63.3%)

1.00

Codominant

A/G

64 (10.5%)

294 (48.2%)

0.66 (0.49,0.88)

0.005*

40 (62.5%)

25 (39.1%)

14.84 (1.68, 130.83)

0.015*

A/A

261 (42.8%)

80 (13.1%)

0.57 (0.35,0.92)

0.021*

6 (9.4%)

11 (17.2%)

3.46 (0.18, 66.82)

0.411

G/G

284 (46.6%)

236 (38.7%)

1.00

18 (28.1%)

28 (43.8%)

1.00

Dominant

A/G + A/A

325 (53.4%)

374 (61.3%)

0.64 (0.48, 0.85)

0.002*

46 (71.9%)

28 (43.8%)

11.82 (1.37,101.80)

0.025*

G/G

284 (46.6%)

236 (37.7%)

1.00

18 (28.1%)

36 (56.2%)

Recessive

A/A

64 (10.5%)

80 (13.1%)

0.71 (0.46, 1.12)

0.140

6 (9.4%)

11 (17.2%)

0.49 (0.05, 4.66)

0.535

G/G + A/G

545 (89.5%)

530 (86.9%)

1.00

58(90.6%)

53 (82.8%)

Log-additive

–

0.73 (0.55, 0.97)

0.029*

0.11 (0.02, 0.55)

0.008*

rs679620

Allele

T

391 (32.1%)

447 (37.2%)

0.80 (0.07, 0.84)

0.018*

52 (40.6%)

49 (38.3%)

1.10 (1.00, 1.46)

0.709

C

827 (67.9%)

753 (62.8%)

1.00

76 (59.4%)

79 (61.7%)

1.00

Codominant

C/T

261 (42.8%)

289 (48.9%)

1.64 (1.02, 2.63)

0.041*

40 (62.5%)

25 (39.1%)

4.19 (0.42, 42.30)

0.224

T/T

65 (10.7%)

79 (13.0%)

1.04 (0.65, 1.66)

0.879

6 (9.4%)

12 (18.8%)

0.30 (0.02, 5.78)

0.422

 C/C

283 (46.4%)

232 (38.0%)

1.00

18 (28.1%)

27 (42.2%)

1.00

Dominant

C/T + T/T

326 (53.5%)

377 (61.9%)

0.62 (0.47, 0.82)

0.001*

46 (71.9%)

37 (52.8%)

11.23 (1.28, 98.20)

0.029*

C/C

283 (46.5%)

232 (38.1%)

1.00

18 (28.1%)

27 (47.2%)

1.00

Recessive

T/T

65 (10.7%)

79 (13.0%)

0.76 (0.50, 1.21)

0.262

6 (9.4%)

12 (18.8%)

0.49 (0.05, 4.66)

0.535

 C/C + C/T

544 (89.3%)

530 (87.0%)

58 (90.6%)

52 (81.2%)

1.00

Log-additive

–

0.69 (0.52, 0.92)

0.010*

0.11 (0.02, 0.59)

0.010*

rs2236302

Allele

G

127 (10.4%)

143 (11.7%)

0.88 (0.35, 1.29)

0.302

9 (7.0%)

12 (9.4%)

0.73 (0.52, 1.00)

0.494

C

1093 (89.6%)

1077 (88.3)

1.00

119 (93.0%)

116 (90.6%)

1.00

Codominant

C/G

113 (18.5%)

135 (22.1%)

2.27 (0.16, 33.07)

0.548

7 (10.9%)

12 (18.8%)

3.388 (0.36, 31.96)

0.286

G/G

7 (1.1%)

4 (0.7%)

2.73 (0.19, 39.23)

0.460

1 (1.6%)

0 (0)

--

--

C/C

490 (80.3%)

471 (77.2%)

1.00

56 (87.5%)

52 (81.2%)

Dominant

C/G-G/G

120 (19.7%)

139 (22.8%)

0.82 (0.58, 1.16)

0.269

8 (12.5%)

12 (18.8%)

0.30 (0.031, 2.78)

0.286

 C/C

490 (80.3%)

471 (77.2%)

1.00

56 (87.5%)

52 (81.2%)

1.00

Recessive

G/G

7 (1.1%)

4 (0.7%)

0.38 (0.03, 5.43)

0.476

1 (1.6%)

0 (0.0)

--

--

C/C-C/G

603 (98.9%)

606 (99.3%)

1.00

63 (98.4%)

64 (100.0%)

1.00

Log-additive

–

1.20 (0.85, 1.70)

0.311

3.39 (0.36, 31.96)

0.286

rs10431961

Allele

T

250 (20.5%)

254 (20.8%)

0.98 (0.75, 1.42)

0.842

19 (14.8%)

28 (21.9%)

0.62 (0.25, 1.64)

0.146

C

970 (79.5%)

966 (79.2%)

1.00

109 (85.2%)

100 (78.1%)

1.00

Codominant

C/T

194 (31.8%)

206 (33.8%)

0.86 (0.43, 1.73)

0.680

13 (20.3%)

26 (40.7%)

0.17 (0.02, 1.76)

0.137

T/T

28 (4.6%)

24 (3.9%)

0.81 (0.39, 1.65)

0.557

3 (4.7%)

1(1.6%)

0.43 (0.04, 4.33)

0.476

 C/C

388 (63.6%)

380 (62.3%)

1.00

48 (75.0%)

37(57.8%)

1.00

Dominant

C/T + T/T

222 (36.4%)

230 (37.7%)

0.96 (0.72, 1.28)

0.769

16 (25.0%)

27 (42.2%)

0.34 (0.07, 1.78)

0.202

 C/C

388 (63.6%)

380 (62.3%)

1.00

48 (75.0%)

37 (57.8%)

1.00

Recessive

T/T

28 (4.6%)

24 (3.9%)

1.18 (0.60, 2.36)

0.630

3 (4.7%)

1 (1.6%)

0.00 (0.00, INF)

1.000

 C/C + C/T

582 (95.4%)

586 (96.1%)

1.00

61 (95.3%)

63 (98.4%)

1.00

Log-additive

–

1.08 (0.80, 1.45)

0.608

2.52 (0.48, 13.34)

0.277