Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study

Yin, Yanling; Zhang, Yu; Zhang, Xiaobo; Zhang, Qi; Wang, Jiachen; Yang, Tian; Liang, Chen; Li, Wu; Liu, Jie; Ma, Xiaojuan; Duan, Jinwei; Shi, Wenzhen; Tian, Ye

doi:10.1186/s12920-023-01734-1

BMC Medical Genomics

Table 4 The SNPs associated with susceptibility of cerebral stroke in the subgroup tests (age and gender)

From: Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study

SNP ID	Model	Genotype	Age				Gender
			OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
			≤ 55 (N = 676)	p	> 55 (N = 672)	p	Male (N = 898)	p	Female (N = 450)	p
rs520540	Allele	A	0.79 (0.63–0.99)	0.039*	0.86 (0.68–1.08)	0.185	0.84 (0.69–1.02)	0.086	0.80 (0.61–1.05)	0.104
		G	1.00		1.00		1.00		1.00
	Codominant	A/G	0.66 (0.47–0.92)	0.014*	0.92 (0.66–1.28)	0.637	0.83 (0.62–1.10)	0.200	0.68 (0.45–1.02)	0.064
		A/A	0.69 (0.41–1.15)	0.156	0.63 (0.38–1.05)	0.074	0.69 (0.44–1.07)	0.097	0.68 (0.35–1.31)	0.245
		G/G	1.00		1.00		1.00		1.00
	Dominant	A/G + A/A	0.67 (0.49–0.91)	0.011*	0.86 (0.63–1.17)	0.329	0.80 (0.61–1.05)	0.101	0.68 (0.46–1.01)	0.054
		G/G	1.00		1.00		1.00		1.00
	Recessive	A/A	0.85 (0.53–1.39)	0.524	0.66 (0.41–1.06)	0.084	0.76 (0.50–1.15)	0.189	0.85 (0.46–1.57)	0.601
		G/G + A/G	1.00		1.00		1.00		1.00
	Log-additive	–	0.77 (0.61–0.97)	0.030*	0.83 (0.66–1.05)	0.119	0.83 (0.68–1.01)	0.066	0.77 (0.57–1.04)	0.089
rs679620	Allele	T	0.80 (0.63-1.00)	0.048*	0.83 (0.67–1.04)	0.111	0.82 (0.68-1.00)	0.053	0.81 (0.62–1.07)	0.137
		C	1.00		1.00		1.00		1.00
	Codominant	C/T	0.63 (0.45–0.88)	0.007*	0.90 (0.65–1.26)	0.552	0.78 (0.58–1.03)	0.082	0.73 (0.48–1.10)	0.129
		T/T	0.75 (0.45–1.25)	0.264	0.58 (0.35–0.98)	0.040*	0.69 (0.44–1.08)	0.102	0.68 (0.35–1.30)	0.240
		C/C	1.00		1.00		1.00		1.00
	Dominant	C/T + T/T	0.65 (0.48–0.89)	0.008*	0.83 (0.61–1.14)	0.247	0.76 (0.58–0.99)	0.045*	0.72 (0.48–1.07)	0.100
		C/C	1.00		1.00		1.00		1.00
	Recessive	T/T	0.95 (0.58–1.54)	0.825	0.62 (0.38-1.00)	0.049*	0.79 (0.52–1.20)	0.261	0.81 (0.44–1.50)	0.504
		C/C + C/T	1.00		1.00		1.00		1.00
	Log-additive	–	0.78 (0.62–0.99)	0.038*	0.81 (0.64–1.02)	0.069	0.81 (0.67–0.99)	0.044*	0.79 (0.59–1.06)	0.120
rs2236302	Allele	G	0.74 (0.51–1.05)	0.093	0.90 (0.65–1.27)	0.558	0.72 (0.53–0.99)	0.039*	1.06 (0.72–1.58)	0.763
		C	1.00		1.00		1.00		1.00
	Codominant	C/G	0.81 (0.54–1.21)	0.298	0.77 (0.53–1.13)	0.184	0.69 (0.49–0.97)	0.035*	1.10 (0.69–1.74)	0.687
		G/G	0.57 (0.11–3.02)	0.506	4.36 (0.52–36.90)	0.176	1.69 (0.40–7.14)	0.479	0.73 (0.14–3.87)	0.712
		C/C	1.00		1.00		1.00		1.00
	Dominant	C/G-G/G	0.79 (0.54–1.18)	0.252	0.83 (0.57–1.20)	0.312	0.72 (0.51–1.01)	0.055	1.07 (0.68–1.68)	0.756
		C/C	1.00		1.00		1.00		1.00
	Recessive	G/G	0.59 (0.11–3.15)	0.538	4.62 (0.55-39.00)	0.160	1.81 (0.43–7.68)	0.418	0.72 (0.14–3.78)	0.694
		C/C-C/G	1.00		1.00		1.00		1.00
	Log-additive	–	0.80 (0.55–1.15)	0.228	0.90 (0.64–1.27)	0.553	0.77 (0.56–1.06)	0.109	1.04 (0.69–1.57)	0.850
rs10431961	Allele	T	0.98 (0.75–1.29)	0.911	0.93 (0.71–1.21)	0.570	0.95 (0.76–1.20)	0.684	0.95 (0.68–1.33)	0.772
		C	1.00		1.00		1.00		1.00
	Codominant	C/T	0.84 (0.60–1.18)	0.312	0.86 (0.62–1.20)	0.380	0.91 (0.68–1.21)	0.525	0.74 (0.49–1.13)	0.163
		T/T	1.47 (0.67–3.22)	0.34	1.19 (0.53–2.64)	0.671	0.99 (0.50–1.93)	0.966	2.24 (0.78–6.46)	0.134
		C/C	1.00		1.00		1.00		1.00
	Dominant	C/T + T/T	0.90 (0.65–1.24)	0.509	0.89 (0.65–1.23)	0.486	0.92 (0.70–1.21)	0.550	0.84 (0.56–1.25)	0.382
		C/C	1.00		1.00		1.00		1.00
	Recessive	T/T	1.55 (0.71–3.37)	0.271	1.25 (0.57–2.76)	0.578	1.02 (0.52–1.98)	0.959	2.46 (0.86–7.02)	0.093
		C/C + C/T	1.00		1.00		1.00		1.00
	Log-additive	–	0.98 (0.74–1.28)	0.861	0.95 (0.72–1.24)	0.690	0.94 (0.75–1.19)	0.625	0.97 (0.69–1.37)	0.869

SNP, Single nucleotide polymorphisms; OR, odds ratio; CI, Confidence interval;
p < 0.05, bold text and ‘*’ indicate statistical significance

Back to article page

ISSN: 1755-8794

Contact us

Submission enquiries: bmcmedicalgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com