Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study

Yin, Yanling; Zhang, Yu; Zhang, Xiaobo; Zhang, Qi; Wang, Jiachen; Yang, Tian; Liang, Chen; Li, Wu; Liu, Jie; Ma, Xiaojuan; Duan, Jinwei; Shi, Wenzhen; Tian, Ye

doi:10.1186/s12920-023-01734-1

BMC Medical Genomics

Table 5 The SNPs associated with susceptibility of cerebral stroke in the subgroup tests (smoking and drinking)

From: Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study

SNP ID	Model	Genotype	Smoking				Drinking
			OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
			Yes (N = 642)	p	No (N = 706)	p	Yes (N = 660)	p	No (N = 688)	p
rs520540	Allele	A	0.87 (0.69–1.09)	0.224	0.79 (0.64–0.98)	0.034*	0.88 (0.70–1.11)	0.279	0.78 (0.62–0.97)	0.024*
		G	1.00		1.00		1.00		1.00
	Codominant	A/G	0.77 (0.55–1.07)	0.122	0.84 (0.61–1.16)	0.287	0.78 (0.56–1.09)	0.144	0.79 (0.57–1.10)	0.201
		A/A	0.85 (0.49–1.46)	0.550	0.66 (0.41–1.08)	0.101	0.85 (0.50–1.43)	0.535	0.61 (0.37–1.02)	0.830
		G/G	1.00		1.00		1.00		1.00
	Dominant	A/G + A/A	0.78 (0.57–1.08)	0.131	0.80 (0.59–1.09)	0.151	0.79 (0.58–1.09)	0.151	0.75 (0.55–1.03)	0.216
		G/G	1.00		1.00		1.00		1.00
	Recessive	A/A	0.97 (0.58–1.63)	0.911	0.73 (0.46–1.15)	0.177	0.96 (0.58–1.58)	0.873	0.69 (0.43–1.12)	0.970
		G/G + A/G	1.00		1.00		1.00		1.00
	Log-additive	–	0.86 (0.68–1.10)	0.233	0.82 (0.66–1.03)	0.087	0.87 (0.69–1.10)	0.253	0.78 (0.62–0.99)	0.290
rs679620	Allele	T	0.88 (0.70–1.11)	0.273	0.77 (0.62–0.96)	0.018*	0.89 (0.71–1.12)	0.316	0.76 (0.61–0.95)	0.014*
		C	1.00		1.00		1.00		1.00
	Codominant	C/T	0.77 (0.55–1.08)	0.133	0.81 (0.58–1.12)	0.195	0.80 (0.57–1.12)	0.187	0.75 (0.54–1.05)	0.091
		T/T	0.90 (0.51–1.56)	0.697	0.63 (0.39–1.03)	0.067	0.86 (0.51–1.46)	0.569	0.59 (0.36–0.99)	0.047*
		C/C	1.00		1.00		1.00		1.00
	Dominant	C/T + T/T	0.79 (0.57–1.09)	0.159	0.77 (0.56–1.04)	0.090	0.81 (0.59–1.11)	0.193	0.72 (0.52–0.98)	0.039*
		C/C	1.00		1.00		1.00		1.00
	Recessive	T/T	1.03 (0.61–1.74)	0.922	0.71 (0.45–1.12)	0.143	0.96 (0.58–1.59)	0.883	0.69 (0.43–1.12)	0.137
		C/C + C/T	1.00		1.00		1.00		1.00
	Log-additive	–	0.88 (0.69–1.12)	0.305	0.80 (0.64-1.00)	0.051	0.88 (0.70–1.12)	0.298	0.76 (0.61–0.97)	0.025*
rs2236302	Allele	G	0.90 (0.63–1.27)	0.533	0.78 (0.55–1.09)	0.146	0.90 (0.65–1.26)	0.553	0.76 (0.53–1.09)	0.129
		C	1.00		1.00		1.00		1.00
	Codominant	C/G	0.92 (0.62–1.38)	0.702	0.72 (0.49–1.05)	0.085	0.80 (0.55–1.18)	0.266	0.84 (0.56–1.25)	0.380
		G/G	0.90 (0.25–3.24)	0.872	2.20 (0.22–22.18)	0.504	2.01 (0.49–8.27)	0.332	0.54 (0.09–3.46)	0.519
		C/C	1.00		1.00		1.00		1.00
	Dominant	C/G-G/G	0.92 (0.63–1.36)	0.686	0.74 (0.50–1.07)	0.111	0.85 (0.59–1.23)	0.393	0.82 (0.55–1.22)	0.331
		C/C	1.00		1.00		1.00		1.00
	Recessive	G/G	0.91 (0.25–3.29)	0.891	2.36 (0.23–23.74)	0.467	2.11 (0.52–8.65)	0.299	0.56 (0.09–3.58)	0.543
		C/C-C/G	1.00		1.00		1.00		1.00
	Log-additive	–	0.93 (0.66–1.32)	0.688	0.77 (0.54–1.11)	0.163	0.92 (0.65–1.29)	0.611	0.82 (0.56–1.19)	0.297
rs10431961	Allele	T	0.93 (0.71–1.22)	0.604	0.98 (0.76–1.26)	0.861	1.05 (0.81–1.37)	0.701	0.87 (0.66–1.13)	0.292
		C	1.00		1.00		1.00		1.00
	Codominant	C/T	0.89 (0.63–1.24)	0.481	0.85 (0.61–1.19)	0.343	0.97 (0.69–1.35)	0.836	0.80 (0.57–1.12)	0.201
		T/T	1.18 (0.45–3.12)	0.737	1.11 (0.55–2.22)	0.775	1.51 (0.66–3.45)	0.323	0.92 (0.42–2.01)	0.830
		C/C	1.00		1.00		1.00		1.00
	Dominant	C/T + T/T	0.91 (0.65–1.26)	0.554	0.88 (0.65–1.21)	0.444	1.01 (0.73–1.40)	0.939	0.82 (0.59–1.13)	0.216
		C/C	1.00		1.00		1.00		1.00
	Recessive	T/T	1.23 (0.47–3.24)	0.672	1.17 (0.59–2.32)	0.661	1.53 (0.68–3.47)	0.304	0.99 (0.45–2.14)	0.970
		C/C + C/T	1.00		1.00		1.00		1.00
	Log-additive	–	0.94 (0.70–1.26)	0.692	0.94 (0.73–1.22)	0.645	1.06 (0.81–1.40)	0.672	0.86 (0.66–1.13)	0.290

SNP, Single nucleotide polymorphisms; OR, odds ratio; CI, confidence interval;
p < 0.05, bold text and ‘*’ indicate statistical significance

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