Evaluation of causal associations between interleukin-18 levels and immune-mediated inflammatory diseases: a Mendelian randomization study

Table 1 Results of analyses for heterogeneity, horizontal pleiotropy and outliers

Exposure	Outcome	P for Cochran’s Q	P for MR-Egger intercept	P for MR-PRESSO global test
IL-18	RA	0.008	0.868	0.019*
	SLE	0.669	0.766	0.711
	IBD	0.905	0.215	0.906
	AS	0.382	0.495	0.417
	PSO	0.107	0.939	0.222
SLE	IL-18	0.267	0.255	0.814
IBD	IL-18	0.770	0.608	0.786

MR Mendelian randomization, MR-PRESSO MR-Pleiotropy Residual Sum and Outlier, IL-18 interleukin-18, RA rheumatoid arthritis, SLE systematic lupus erythematosus, IBD inflammatory bowel disease, AS ankylosing spondylitis, PsO psoriasis
^*No significant outliers were identified

ISSN: 1755-8794