SNP | Normal Control (N = 100) | Cirrhotic patients (N = 100) | HCC patients (N = 99) | Cirrhotic patients vs normal controls | HCC patients vs normal controls | Cirrhotic patients vs HCC patients | |||
---|---|---|---|---|---|---|---|---|---|
 |  | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | ||
VDR (rs2228570) | |||||||||
 CC | 34 (34%) | 54 (54%) | 46 (46.5%) | 2.279 (1.283–4.033) | p < 0.01 | 1.685 (0.951–2.985) | p < 0.05 | 0.739 (0.423–1.291) | NS |
 CT | 48 (48%) | 26 (26%) | 32 (32.3%) | 0.381 (0.210–0.690) | p < 0.001 | 0.517 (0.291–0.920) | p < 0.05 | 1.359 (0.736–2.512) | NS |
 TT | 18 (18%) | 20 (20%) | 21 (21.2%) | 1.139 (0.561–2.310) | NS | 1.122 (0.608–2.474) | NS | 1.077 (0.542–2.141) | NS |
 CTTT | 66 (66%) | 46 (46%) | 53 (53.5%) | 0.44 (0.25–0.78) | p < 0.001 | 0.59 (0.33–1.05) | NS | 1.35 (0.774–2.361) | NS |
 C | 116 (58%) | 134 (67%) | 124 (63%) | 1.470 (0.978–2.208) | NS | 1.121 (0.816–1.814) | NS | 0.825 (0.546–1.246) | NS |
 T | 84 (42%) | 66 (33%) | 74 (37%) | 0.630 (0.152–1.021) | NS | 0.824(0.551–1.234) | NS | 1.211 (0.802–1.829) | NS |
VDR (rs3782905) | |||||||||
 GG | 51 (51%) | 19 (19%) | 23 (23.2%) | 0.225 (0.119–0.425) | p < 0.001 | 0.291 (0.158–0.535) | p < 0.001 | 1.290 (0.651–2.556) | NS |
 GC | 29 (29%) | 30 (30%) | 45 (45.5%) | 1.049 (0.571–1.927) | NS | 2.040 (1.136–3.665) | p < 0.05 | 1.944 (1.036–3.482) | p < 0.05 |
 CC | 20 (20%) | 51 (51%) | 31 (31.3%) | 4.163 (2.223–7.798) | p < 0.001 | 1.82 (0.953–3.488) | p < 0.05 | 0.438 (0.246–0.781) | p < 0.01 |
 GCCC | 49 (49%) | 81 (81%) | 76 (67.8%) | 0.24 (0.13–0.45) | p < 0.001 | 3.44 (1.87–6.33) | p < 0.001 | 0.77 (0.39–1.5) | NS |
 G | 69 (34%) | 132 (66%) | 107 (54%) | 3.685 (2.438–5.570) | p < 0.001 | 2.232 (1.490–3.341) | p < 0.001 | 0.605 (0.404–0.907) | p < 0.05 |
 C | 131 (66%) | 68 (34%) | 91 (46%) | 0.271 (0.179–0.410) | p < 0.001 | 0.448 (0.299–0.670) | p < 0.001 | 1.650 (1.104–2.474) | p < 0.05 |
VDR(rs11568820) | |||||||||
 GG | 0 (0%) | 0 (0%) | 0 (0%) | –––––––––- | ––– | –––––––––- | ––– | –––––––––- | ––– |
 GA | 100 (100%) | 100 (100%) | 99 (100%) | –––––––––- | ––– | –––––––––- | ––– | –––––––––- | ––– |
 AA | 0 (0%) | 0 (0%) | 0 (0%) | –––––––––- | ––– | –––––––––- | ––– | –––––––––- | ––– |
 G | 100 (50%) | 100 (50%) | 100 (50%) | –––––––––- | ––– |  |  |  |  |
 A | 100 (50%) | 100 (50%) | 100 (50%) | –––––––––- | ––– |  |  |  |  |
DBP (rs7041) | |||||||||
 TT | 61 (61%) | 23 (23%) | 20 (20.2%) | 0.191 (0.103–0.353) | p < 0.001 | 0.162 (0.066–0.305) | p < 0.001 | 0.848 (0.431–1.807) | NS |
 TG | 23 (23%) | 49 (49%) | 29 (29.3%) | 3.21 (1.750–5.913) | p < 0.001 | 1.387 (0.734–2.619) | NS | 0.431 (0.240–0.773) | p < 0.01 |
 GG | 16 (16%) | 28 (28%) | 50 (50.5%) | 2.642 (1.024–4.071) | p < 0.05 | 5.357 (2.757–10.408) | p < 0.001 | 2.624 (1.457–4.724) | p < 0.001 |
 TGGG | 39 (39%) | 77 (77%) | 79 (79.8%) | 5.24 (2.83–6.69) | p < 0.001 | 6.18 (3.28–11.65) | p < 0.001 | 1.17 (0.59–2.32) | NS |
 T | 145 (72%) | 95 (48%) | 129 (65%) | 0.343 (0.226–0.520) | p < 0.001 | 0.709 (0.463–1.086) | NS | 1.082 (0.695–1.684) | NS |
 G | 55 (28%) | 105 (52%) | 69 (35%) | 2.913 (1.921–4.418) | p < 0.001 | 1.410 (0.920–2.159) | NS | 1.410 (0.920–2.159) | NS |