Fig. 3

(A) Identifying the differentially expressed miRNAs by a volcano plot. The two vertical lines are the 2-fold change boundaries and the horizontal line is the statistical significance boundary (Adj P-value < 0.05). The statistically significant up-regulated and the down-regulated miRNAs with a 2-fold change ≥ 2 are marked with red and blue dots respectively. (B) Heatmap generated by clustering differentially expressed miRNAs in DOR and Normal exosomes. The color bar represents a relative expression, “red” indicates a high relative expression and “blue” indicates a low relative expression