Table 1 Demographic, clinical characteristics and laboratory parameters of COVID-19 patients and healthy subject*
SNP_ID | IL10 rs1800872 (− 592) | IL10 rs1800896 (− 1082) | TNFa rs1800629 (-308) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotypes/Variables | AA | CA | CC | p value | p value** | AA | AG | GG | p value | p value** | AG | GG | p value |
Age (years, Mean ± SD) | 56.2 ± 16.3 | 58.4 ± 13.2 | 50.1 ± 22.9 | 0.4 | P1 = 1 P2 = 1 P3 = 0.6 | 57.4 ± 15.1 | 51.5 ± 13.6 | 59.5 ± 16.3 | 0.23 | P4 = 0.4 P5 = 1 P6 = 0.2 | 56.3 ± 16.1 | 57.1 ± 15.1 | 0.89 |
Sex | |||||||||||||
Male | 25 | 30 | 2 | 0.6 | - | 33 | 8 | 16 | 0.52 | 14 | 43 | 0.19 | |
Female | 23 | 25 | 5 | - | 35 | 9 | 9 | 7 | 46 | ||||
Diabetes Mellitus | |||||||||||||
Positive | 22 | 25 | 2 | 0.8 | - | 28 | 10 | 13 | 0.39 | - | 7 | 42 | 0.34 |
Negative | 27 | 30 | 4 | - | 41 | 7 | 11 | - | 13 | 48 | |||
Hypertension | |||||||||||||
Positive | 19 | 23 | 1 | 0.4 | - | 28 | 7 | 8 | 0.8 | - | 4 | 39 | 0.04 |
Negative | 30 | 32 | 5 | - | 41 | 10 | 16 | - | 16 | 51 | |||
CKD | - | - | |||||||||||
Positive | 1 | 0 | 1 | 0.015 | - | 2 | 0 | 0 | 0.54 | - | 0 | 2 | 0.50 |
Negative | 48 | 55 | 5 | - | 67 | 17 | 24 | - | 20 | 88 | |||
PCR test | 47 | 56 | 7 | 68 | 17 | 25 | 20 | 90 | |||||
Positive | 38(43%) | 44 | 7 | 0.3965 | 52 | 14 | 23 | 0.2368 | 13 | 76 | 0.04536 | ||
Negative | 9(19%) | 12 | 0 | 16 | 3 | 2 | 7 | 14 | |||||
White blood cell count (/µl) | 11,020 ± 0.04 | 11,091 ± 0.04 | 10,000 ± 0.001 | 0.7 | P1 = 1 P2 = 1 P3 = 1 | 1.1159 ± 0.03 | 1.0588 ± 0.05 | 1.0833 ± 0.05 | 0.75 | P4 = 1 P5 = 1 P6-1 | 11,000 ± 0.06 | 11,000 ± 0.03 | 1.0 |
Lymphocytes (/µl) | 1820.3 ± 618.9 | 11399.1 ± 200.3 | 1197 ± 259.8 | 0.7 | P1 = 1 P2 = 1 P3 = 1 | 1129.8 ± 85.1 | 3845.4 ± 1802.1 | 1249.9 ± 110.2 | 0.86 | P4 = 0.003 P5 = 1 P6 = 0.019 | 1139.7 ± 126.4 | 1672.6 ± 356.3 | 0.48 |
C reactive protein (mg/l) | 81.3 ± 9.3 | 63.6 ± 9.1 | 66.4 ± 26.8 | 0.3 | P1 = 0.5 P2 = 1 P3 = 1 | 73.7 ± 7.1 | 32.2 ± 5.7 | 93.5 ± 19.1 | 0.19 | P4 = 0.05 P5 = 0.5 P6 = 0.01 | 69.4 ± 14.6 | 72.1 ± 7 | 0.87 |
Ferritin (ng/ml) | 561.7 ± 72.03 | 476.9 ± 66.6 | 552.1 ± 134.2 | 0.6 | P1 = 1 P2 = 1 P3 = 1 | 556.2 ± 61.1 | 352.5 ± 73.9 | 529 ± 110.1 | 0.81 | P4 = 0.3 P5 = 1 P6 = 0.7 | 491.3 ± 93 | 523.3 ± 53.2 | 0.79 |
D-Dimer (ng/ml) | 1282.4 ± 295.2 | 752.8 ± 138.1 | 1639 ± 731 | 0.1 | P1 = 1 P2 = 0.2 P3 = 0.6 | 983.2 ± 592.4 | 755.5 ± 272.4 | 1520.8 ± 463.2 | 0.13 | P4 = 1 P5 = 0.3 P6 = 0.4 | 612.6 ± 111.3 | 1131.4 ± 168.3 | 0.19 |
LDH (U/l) | 423.3 ± 41.7 | 401.9 ± 45.8 | 330.3 ± 52.3 | 0.7 | P1 = 1 P2 = 1 P3 = 1 | 415.3 ± 40.5 | 307.1 ± 39.8 | 458.1 ± 61.1 | 0.56 | P4 = 0.5 P5 = 1 P6 = 0.3 | 408.8 ± 47.5 | 407.1 ± 34.6 | 0.98 |