Table 2 Genotype distribution of IL-10 and TNFa polymorphisms in COVID-19 patients versus healthy subjects
Gene | SNP_ID | Alleles and Genotype | Cases n = 110 (%) | Controls n = 110(%) | Adjusted OR* (95% CI) | p value** |
|---|---|---|---|---|---|---|
IL-10 | rs1800872 (− 592) | A | 150(68) | 92(42) | Reference | |
C | 70 (32) | 128(58) | 2.9814 (2.0181 to 4.4043) | p < 0.0001 | ||
CC | 7(6) | 24(22) | Reference | |||
CA | 56(51) | 80(73) | 0.0734(0.0291 to 0.1849) | p < 0.0001 | ||
AA | 47(43) | 6(5) | 0.0372 (0.0113 to 0.1232) | p < 0.0001 | ||
X2HWE*** (p-value) | 0.083 | < 0.0001 | ||||
IL-10 | rs1800896 (− 1082) | A | 152(70) | 136(62) | Reference | |
G | 64(30) | 84(38) | 0.6817(0.4574 to 1.0161) | p = 0.0599 | ||
AA | 68(63) | 37(34) | Reference | |||
GA | 16(15) | 62(56) | 0.1404(0.0711 to 0.2772) | p = 0.0599 | ||
GG | 24(22) | 11(10) | 1.1872(0.5238 to 2.6909) | p = 0.6811 | ||
X2 HWE (p-value) | < 0.0001 | 0.068 | ||||
TNFa | rs1800629 (-308) | G | 200(91) | 220(100) | Reference | - |
A | 20(9) | 0 | 45.0898 (2.7093 to 750.4146) | p = 0.0079 | ||
GG | 90 (81.8) | 110 (100) | Reference | |||
GA | 20 (18.2) | 0 (0) | 50.0608(2.9863 to 839.1787) | p = 0.0065 | ||
AA | 0 | 0 | 1.2210(0.0240 to 62.1470) | p = 0.9207 | ||
X2 HWE (p value) | 0.6 | 1 |