Table 3 Genotype frequencies of IL-10 studied SNPs in COVID-19 patients versus healthy subjects under different inheritance models
SNP-ID | Model | Genotypes | COVID-19 patients(n = 110) (%) | Healthy subjects (n = 110) (%) | OR* (95% CI) | p- value** |
|---|---|---|---|---|---|---|
rs1800872 | Co dominant | AA | 46(42.2) | 6 (5.5) | 1.00 | |
CA | 56(51.4) | 80 (72.7) | 11.20 (4.44–28.23) | < 0.0001 | ||
CC | 7(6.4) | 24 (21.8) | 25.93 (7.76–86.60) | |||
Dominant | AA | 46 (42.2%) | 6 (5.5%) | 1.00 | ||
CA + CC | 63 (57.8%) | 104 (94.5%) | 12.89 (5.17–32.16) | < 0.0001 | ||
Recessive | AA + CA | 102 (93.6) | 86 (78.2%) | 1.00 | ||
CC | 7 (6.4) | 24 (21.8%) | 3.95 (1.61–9.68) | < 0.0001 | ||
Over Dominant | AA + CC | 53 (48.6) | 30 (27.3) | 1.00 | ||
CA | 56 (51.4) | 80 (72.7) | 2.60 (1.47–4.60) | < 0.0001 | ||
Log-additive | --- | --- | --- | 5.68 (3.09–10.43) | < 0.0001 | |
rs1800896 | Co dominant | AA | 68 (63%) | 37 (33.6%) | 1.00 | |
GA | 16 (14.8%) | 62 (56.4%) | 7.12 (3.61–14.06) | < 0.0001 | ||
GG | 24 (22.2%) | 11 (10%) | 0.84 (0.37–1.91) | |||
Dominant | AA | 68 (63%) | 37 (33.6%) | 1.00 | ||
GA + GG | 40 (37%) | 73 (66.4%) | 3.35 (1.92–5.85) | < 0.0001 | ||
Recessive | AA + GA | 84 (77.8%) | 99 (90%) | 1.00 | ||
GG | 24 (22.2%) | 11 (10%) | 0.39 (0.18–0.84) | 0.013 | ||
Over Dominant | AA + GG | 92 (85.2%) | 48 (43.6%) | 1.00 | ||
GA | 16 (14.8%) | 62 (56.4%) | 7.43 (3.87–14.24) | < 0.0001 | ||
Log-additive | --- | --- | 1.38 (0.95–1.99) | 0.085 |