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Table 4 Haplotype frequencies and distribution of IL-10 and TNFa in COVID-19 patients versus healthy subjects (n = 220)

From: Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes

IL-10

(-592)

IL-10

(-1082)

Frequency

OR (95% CI)

p-value

A

A

0.4456

1.00

---

C

G

0.2388

16.97 (6.36–45.29)

< 0.0001

C

A

0.2112

1.72 (0.84–3.54)

0.14

A

G

0.1044

0.00 (-Inf - Inf)

1

IL-10

haplotypes

TNFa

(-308)

Frequency

OR (95% CI)

p-value

H1(AA)

G

0.4277

1.00

---

H2(CG)

G

0.2398

14.07 (5.28–37.50)

< 0.0001

H3(CA)

G

0.2004

1.72 (0.82–3.59)

0.15

H4(AG)

G

0.0866

0.00 (-Inf - Inf)

1

  1. OR, un-adjusted odds ratio, CI, Confidence interval, p value < 0.05 was considered as significant. Global haplotype association p-value: <0.0001. Haplotypes for the IL-10 polymorphisms are in the first part. No significant OR were identified with TNF1 A allele
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BMC Medical Genomics

ISSN: 1755-8794

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