Table 5 Association of inheritance models of IL-10 and TNFa SNPs with clinical and laboratory severity*
SNP_ID | Model | Genotype | OR(CI) (p value) | |||
|---|---|---|---|---|---|---|
O2 therapy | HRCT | Ferritin | D-Dimer | |||
rs1800872 | Co dominant | AA | 1.00 | 1.00 | 1.00 | 1.00 |
CA | 0.95 (0.41–2.21) (0.98) | 0.47 (0.20–1.10) (0.12) | 0.62 (0.19–2.06) (0.37) | 1.10 (0.49–2.49) (0.91) | ||
CC | 0.85 (0.15–4.91) | 0.25 (0.03–2.21) | 1.90 (0.50–7.27) | 1.42 (0.25–8.11) | ||
Dominant | AA | 1.00 | 1.00 | 1.00 | 1.00 | |
CA + CC | 0.94 (0.42–2.13) (0.89) | 0.44 (0.19–1.01) (0.051) | 1.10 (0.42–2.90) (0.84) | 1.13 (0.51–2.50) (0.76) | ||
Recessive | AA + CA | 1.00 | 1.00 | 1.00 | 1.00 | |
CC | 0.88 (0.16–4.75) (0.88) | 0.36 (0.04–3.11) (0.3) | 2.11 (0.57–7.82) (0.23) | 1.34 (0.25–7.27) (0.73) | ||
Over dominant | AA + CC | 1.00 | 1.00 | 1.00 | 1.00 | |
CA | 0.97 (0.43–2.19) (0.95) | 0.54 (0.23–1.24) (0.14) | 0.54 (0.17–1.73) (0.31) | 1.06 (0.48–2.32) (0.89) | ||
Log additive | 0.94 (0.48–1.85) (0.86) | 0.48 (0.23–0.99) (0.04) | 1.23 (0.68–2.22) (0.49) | 1.14 (0.59–2.21) (0.69) | ||
rs1800896 | Co dominant | AA | 1.00 | 1.00 | 1.00 | 1.00 |
GA | 2.02 (0.66–6.14) (0.15) | 1.87 (0.59–5.97) (0.13) | 0.47 (0.14–1.66) (0.32) | 0.94 (0.32–2.77) (0.066) | ||
GG | 2.44 (0.92–6.46) | 2.64 (0.99–7.05) (0.13) | 1.62 (0.41–6.36) (0.32) | 3.46 (1.07–11.19) (0.066) | ||
Dominant | AA | 1.00 | 1.00 | 1.00 | 1.00 | |
GA + GG | 2.26 (0.99–5.16) (0.053) | 2.31 (0.99–5.36) (0.051) | 0.90 (0.33–2.46) (0.84) | 1.86 (0.80–4.31) (0.14) | ||
Recessive | AA + GA | 1.00 | 1.00 | 1.00 | 1.00 | |
GG | 2.08 (0.82–5.29) 0.13 | 2.31 (0.90–5.91) (0.084) | 1.91 (0.50–7.21) (0.32) | 3.50 (1.10–11.10) (0.02) | ||
Over dominant | AA + GG | 1.00 | 1.00 | 1.00 | 1.00 | |
GA | 1.55 (0.53–4.49) 0.42 | 1.40 (0.46–4.24) (0.56) | 0.42 (0.12–1.43) 0.18) | 0.71 (0.25–2.06) (0.54) | ||
Log additive | 1.64 (1.01–2.66) (0.45) | 1.12 (0.61–2.04) (0.71) | 1.63 (0.96–2.76) (0.06) | |||
rs1800629 | --- | GG | 1.00 | 1.00 | 1.00 | 1.00 |
--- | AG | 1.56 (0.57–4.24) (0.39) | 0.73 (0.24–2.20) (0.56) | 1.09 (0.32–3.73) (0.89) | 1.29 (0.45–3.68) (0.63) | |