Table 6 Association between IL-10 and TNFa SNPs with condition at discharge
SNP_ID | Model | Genotypes | Survived (n = 87) (%) | Deceased (n = 23) (%) | OR* (95% CI) | p- value** |
|---|---|---|---|---|---|---|
rs1800872 | Co dominant | AA | 35 (40.2%) | 12 (52.2%) | 1.00 | |
CA | 45 (51.7%) | 11 (47.8%) | 0.67 (0.23–1.98) | 0.27 | ||
CC | 7 (8.1%) | 0 (0%) | 0.00 (0.00-NA) | |||
Dominant | AA | 35 (40.2%) | 12 (52.2%) | 1.00 | 0.37 | |
CA + CC | 52 (59.8%) | 11 (47.8%) | 0.61 (0.21–1.80) | |||
Recessive | AA + CA | 80 (92%) | 23 (100%) | 1.00 | 0.15 | |
CC | 7 (8.1%) | 0 (0%) | 0.00 (0.00-NA) | |||
Over Dominant | AA + CC | 42 (48.3%) | 12 (52.2%) | 1.00 | 0.68 | |
CA | 45 (51.7%) | 11 (47.8%) | 0.80 (0.27–2.31) | |||
Log-additive | --- | --- | --- | 0.55 (0.20–1.47) | 0.23 | |
X2 HWE*** (p value) | 0.23 | 0.28 | ||||
rs1800896 | Co dominant | AA | 57 (65.5%) | 11 (47.8%) | 1.00 | 0.42 |
GA | 13 (14.9%) | 4 (17.4%) | 0.70 (0.14–3.40) | |||
GG | 17 (19.5%) | 8 (34.8%) | 1.94 (0.57–6.58) | |||
Dominant | AA | 57 (65.5%) | 11 (47.8%) | 1.00 | 0.59 | |
GA + GG | 30 (34.5%) | 12 (52.2%) | 1.35 (0.46–3.97) | |||
Recessive | AA + GA | 70 (80.5%) | 15 (65.2%) | 1.00 | 0.21 | |
GG | 17 (19.5%) | 8 (34.8%) | 2.11 (0.66–6.76) | |||
Over Dominant | AA + GG | 74 (85.1%) | 19 (82.6%) | 1.00 | 0.42 | |
GA | 13 (14.9%) | 4 (17.4%) | 0.55 (0.12–2.49) | |||
Log-additive | --- | --- | --- | 1.35 (0.73–2.50) | 0.34 | |
X2 HWE (p value) | --- | --- | < 0.0001 | < 0.0001 | ||
rs1800629 | --- | GG | 75 (86.2%) | 15 (65.2%) | 1.00 | --- |
--- | AG | 12 (13.8%) | 8 (34.8%) | 3.3(1.16–9.54) | 0.024 | |
X2 HWE (p value) | --- | 1 | 1 | - | - | - |