Table 2 Comparisons of genotype distribution, allele frequency, and genetic models of rs10754558, rs7525979, rs35829419 and rs4612666 between the COM patients and healthy controls
SNPs | Item | Allele or genotype | Patients | Controls | P values | OR (95% CI) |
|---|---|---|---|---|---|---|
rs10754558 | Genotype (n, %) | CC | 139 (32.48) | 135 (36.68) | 0.053 | NA |
| Â | CG | 232 (54.21) | 169 (45.92) | |||
| Â | GG | 57 (13.32) | 64 (17.39) | |||
Allele frequency | C vs. G | 510/346 | 439/297 | 0.978 | 0.997 (0.816–1.219) | |
Dominant model | CC + CG vs. GG | 371/57 | 304/64 | 0.110 | 1.370 (0.930–2.019) | |
Recessive model | CC vs. CG + GG | 139/289 | 135/233 | 0.213 | 0.830 (0.619–1.113) | |
Homozygous model | CC vs. GG | 139/57 | 135/64 | 0.507 | 1.156 (0.753–1.774) | |
Heterozygous model | CG vs. GG | 232/57 | 169/64 | 0.037 | 1.541 (1.025–2.319) | |
rs7525979 | Genotype (n, %) | TT | 8 (1.87) | 14 (3.84) | 0.120 | NA |
CT | 106 (24.77) | 102 (27.95) | ||||
CC | 314 (73.36) | 249 (68.22) | ||||
Allele frequency | T vs. C | 122/734 | 130/600 | 0.054 | 0.767 (0.586–1.004) | |
Dominant model | TT + CT vs. CC | 114/314 | 116/249 | 0.112 | 0.779 (0.573–1.060) | |
Recessive model | TT vs. CT + CC | 8/420 | 14/351 | 0.093 | 0.478 (0.198–1.151) | |
Homozygous model | TT vs. CC | 8/314 | 14/249 | 0.073 | 0.453 (0.187–1.097) | |
Heterozygous model | CT vs. CC | 106/314 | 102/249 | 0.234 | 0.824 (0.599–1.133) | |
rs35829419 | Genotype (n, %) | AA | 0 (0.0) | 0 (0.0) | NA | NA |
AC | 3 (0.70) | 1 (0.27) | ||||
CC | 424 (99.30) | 367 (99.73) | ||||
Allele frequency | A vs. C | 3/851 | 1/735 | 0.724 | 2.591 (0.269–24.963) | |
Dominant model | AA + AC vs. CC | 3/424 | 1/367 | 0.724 | 2.597 (0.269– 25.071) | |
Recessive model | AA vs. AC + CC | 0/427 | 0/368 | NA | NA | |
Homozygous model | AA vs. CC | 0/424 | 0/367 | NA | NA | |
Heterozygous model | AC vs. CC | 3/424 | 1/367 | 0.724 | 2.597 (0.269–25.071) | |
rs4612666 | Genotype (n, %) | CC | 114 (26.64) | 98 (26.63) | 0.422 | NA |
CT | 224 (52.34) | 179 (48.64) | ||||
TT | 90 (21.03) | 91 (24.73) | ||||
Allele frequency | C vs. T | 452/404 | 375/361 | 0.461 | 1.077 (0.884–1.312) | |
Dominant model | CC + CT vs. TT | 338/90 | 277/91 | 0.214 | 1.234 (0.885–1.719) | |
Recessive model | CC vs. GT + TT | 114/314 | 98/270 | 0.999 | 1.000 (0.730–1.371) | |
Homozygous model | CC vs. TT | 114/90 | 98/91 | 0.423 | 1.176 (0.791–1.750) | |
Heterozygous model | CT vs. TT | 224/90 | 179/91 | 0.189 | 1.265 (0.890–1.798) |