Table 4 Previously reported SNP sites associating with OM development
PMID | Gene | SNPs | Chr: Pos | Action of SNPs | Pathway* | OM or OM type |
|---|---|---|---|---|---|---|
35957979 | VDR | rs7975232 | 12:48238837 | Cis-eQTL | Generic Transcription Pathway | COM |
rs1544410 | 12:48239835 | Cis-eQTL | Generic Transcription Pathway | |||
34628386 | IL-1β PON1 | rs1143634 | 2:113590390 | Cis-eQTL | Interleukin-4 and Interleukin-13 signaling | OM |
rs705379 | 7:94953895 | Not found | Atorvastatin ADME | |||
32542640 | CRP | rs11265260 | 1:159700039 | Not found | Classical antibody-mediated complement activation | DFO |
rs1800947 | 1:159683438 | Not found | Classical antibody-mediated complement activation | |||
rs3093059 | 1:159685136 | Not found | Classical antibody-mediated complement activation | |||
rs1130864 | 1:159683091 | Not found | Classical antibody-mediated complement activation | |||
32454789 | IL-1β IL-6 IL-1RN | rs16944 | 2:113594867 | Cis-eQTL | Signaling by Interleukins | PTOM |
rs1143627 | 2:113594387 | Cis-eQTL | Cell recruitment (pro-inflammatory response) | |||
rs1800796 | 7:22766246 | Cis-eQTL | Not found | |||
rs4251961 | 2:113874467 | Cis-eQTL | Interleukin-1 family signaling | |||
31746120 | IFN-γ | rs2430561 | 12:68552522 | Cis-eQTL | Not found | PTOM |
31647805 | CTSG | rs45567233 | 14:25043671 | Cis-eQTL | Cell recruitment (pro-inflammatory response) | OM |
30949508 | IL-1β | rs16944 | 2:113594867 | Cis-eQTL | Interleukin-1 family signaling | COM |
30259788 | TNF-α | rs1799964 | 6:31542308 | Cis-eQTL | Cytokine Signaling in Immune system | COM |
29049163 | MMP-1 | rs1799750 | 11:102670496 | Cis-eQTL | Cytokine Signaling in Immune system | OM |
rs1144393 | 11:102669409 | Cis-eQTL | Cytokine Signaling in Immune system | |||
27329975 | VDR | rs731236 | 12:48238757 | Cis-eQTL | Vitamin D (calciferol) metabolism | COM |
rs2228570 | 12:48272895 | Cis-eQTL | Generic Transcription Pathway | |||
27323068 | IL-1β TLR-2 | rs16944 | 2:113594867 | Cis-eQTL | Vitamin D (calciferol) metabolism | HO |
rs3804099 | 4:154624656 | Cis-eQTL | Neutrophil degranulation | |||
26681045 | IL-4 IL-10 | rs2070874 | 5:132009710 | Cis-eQTL | Cytokine Signaling in Immune system | HO |
rs1800871 | 1:206946634 | Cis-eQTL | CD163 mediating an anti-inflammatory response | |||
28682162 | COX-2 | rs689466 | 1:186650751 | Cis-eQTL | Interleukin-10 signaling | PTOM |
23570848 | tPA | rs4646972 | Not found | Not found | Not found | OM |
19821768 | MMP-1 | rs1799750 | 11:102670496 | Cis-eQTL | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | OM |
18971305 | IL-1α IL-4 IL-6 | rs1800587 | 2:113542960 | Cis-eQTL | Cell recruitment (pro-inflammatory response) | COM |
rs2243248 | 5:132008644 | Cis-eQTL | Interleukin-4 and Interleukin-13 signaling | |||
rs2243250 | 5:132009154 | Cis-eQTL | Cytokine Signaling in Immune system | |||
rs1800795 | 7:22766645 | Not found | Not found | |||
17438390 | BAX | rs4645878 | 19:49457938 | Cis-eQTL | Apoptosis | OM |
16487238 | TLR4 | rs4986790 | 9:120475302 | Cis-eQTL | MyD88 dependent cascade initiated on endosome | HO |
The present study | NLRP3 | rs10754558 | 1:247612036 | Cis-eQTL | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | COM |
rs7525979 | 1:247587408 | Cis-eQTL | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |