Table 4 Haplotypes of four families based on genetic linkage analyses
Family | Family relationship | Haplotype of HBA | Genotypes of HBA | Haplotype of HBB | Genotypes of HBB |
|---|---|---|---|---|---|
Family 1 | Husband 1 | / | / | F0/F1 | Codons 41/42(-TTCT)/βN |
Wife 1 | / | / | M0/M1 | Gγ(Aγδβ)0/βN | |
Offspring 1–1 (Proband) | / | / | M0/F0 | Codons 41/42(-TTCT)/Gγ(Aγδβ)0 | |
Offspring 1–2 (Simulated embryo) | / | / | M0/F1 | Gγ(Aγδβ)0/βN | |
Family 2 | Husband 2 | F0/F1 | --SEA/αα | / | / |
Wife 2 | M0/M1 | ααCS/αα | / | / | |
Offspring 2 − 1 (Proband) | M0/F0 | --SEA/ααCS | / | / | |
Offspring 2–2 (Simulated embryo) | M0/F1 | ααCS/αα | / | / | |
Family 3 | Husband 3 | / | / | F0/F1 | Gγ(Aγδβ)0/βN |
Wife 3 | / | / | M0/M1 | Codons 41/42(-TTCT)/βN | |
Offspring 3 − 1 (Proband) | / | / | M0/F0 | Gγ(Aγδβ)0/ Codons 41/42(-TTCT) | |
Offspring 3 − 2 (Simulated embryo) | / | / | M1/F0 | Gγ(Aγδβ)0/βN | |
Family 4 | Husband 4 | / | / | F0/F1 | IVS-II-654 (C > T)/βN |
Wife 4 | / | / | M0/M1 | IVS-II-654 (C > T)/βN | |
Offspring 4 − 1 (Proband) | / | / | M0/F0 | IVS-II-654 (C > T)/IVS-II-654 (C > T) | |
Offspring 4 − 2 (Simulated embryo) | / | / | M1/F0 | IVS-II-654 (C > T)/βN |