Fig. 4

Figure representing in-depth analysis of 5 patients with ER + /HER2- breast cancer. The antigen counts in tumor with antigen-presenting (AP) scores >  = 0.5 and >  = 0.7 are shown in the tables on the left side of the figure. The AP scores >  = 0.5 and >  = 0.7 are indicative of an increased likelihood of presenting the candidate neoantigen peptides. Radar plots in the middle of the figure display personalized HLA/B2M expression in tumor (green) versus matched normal adjacent tissues (gray). The numbers on the axes correspond to the TPM values of the HLA genes. The relative position of axes and the angles between the axes represent no biological meaning. HLA-E expression is shown in bar plots in the footnote of each radar plot. The radar plots on the right show immune cell fractions for tumor (green) and normal adjacent to tumor tissues (gray)