Fig. 5

Communities of IRGs (A) The association of Communities and HGSs. B Right: Relationship between Community 1 and genes disturbed by HH pathway. Left: Relationship between Community 1 related genes confirmed by RWR algorithm and HH pathway genes. C Kaplan–Meier curves of IWHMB of HH in high and low groups of TCGA HNSCC and chen’s cohorts. D Kaplan–Meier curves and Cox regression models of the MEC1 in multiple HNSCC cohorts. E Association of Community 1 with distant metastases in the TCGA HNSCC cohort. F Association of Community 1 with clinical stage in multiple HNSCC cohorts. G The proportion of differential expressed genes contained in the Communities. H Correlation between the MEC1 and two kind of tumor stemness scores. I Association of Community 1 with immune scores in multiple HNSCC cohorts. J Relationship between Community 1 and the relative content of 22 immune cells in multiple HNSCC cohorts