Fig. 6

Relationship between Community 1 and EMT in TME of HNSCC (A) The trajectory of EMT based on mesenchymal cells and malignant epithelial cells. B Distribution of eks along EMT trajectory. C Change of Community 1 module score on EMT trajectory. D The relationship between Community 1 module score and pseudotime of EMT trajectory. E Correlation between the GSVA score of Community 1 and 7 HGSs in single-cell level. F Gene heatmap of EMT trajectory and pathway enrichment features in four different periods by pseudotime. G, H Association of eks with classical cell types and four time periods by pseudotime. I Cell-to-cell communication in eks. J Evolution of genes in Community 1 associated with pathological grades in EMT trajectories. K Biological characterization of eks. L Unique transcription factor AUC scores for eks