Fig. 2

Manhattan plots for associations of genetically predicted circulating proteins levels with HF in MR analysis. (a) Associations of genetically predicted circulating proteins with HF in patients with CHD; (b) Associations of genetically predicted circulating proteins with HF in patients receiving antihypertensive medication. Labelled and colored proteins refer to MR findings with Bonferroni-corrected P < 0.05 (two-sample MR analysis). Red proteins indicate the positive effect of the circulating proteins on outcomes; blue proteins indicate the negative effect of the circulating proteins on outcomes; blue line indicates the Bonferroni-corrected P value equals to 0.05. Results are plotted by gene start position