Table 1 Mendelian randomization and colocalization analyses of circulating proteins on HF outcomes: Insights from the ARIC dataset. HF: heart failure; CHD: Coronary heart disease; CI, Confidence interval; BF, Bonferroni; OR, Odds ratio
Outcomes | Proteins | OR (95% CI) | P value | BF-corrected P value | Colocalization Analysis PH4 (%) |
|---|---|---|---|---|---|
HF in patients with CHD | PCSK9 | 1.273 (1.165–1.390) | 8.18E-08 | 1.45E-04 | 99.998 |
HF in patients with CHD | AIDA | 0.768 (0.681–0.867) | 1.88E-05 | 3.33E-02 | 92.621 |
HF in patients receiving antihypertensive medication | PCSK9 | 1.145 (1.084–1.210) | 1.41E-06 | 2.50E-03 | 98.864 |
HF in patients receiving antihypertensive medication | SWAP70 | 0.906 (0.870–0.945) | 3.10E-06 | 5.50E-03 | 81.718 |
HF in patients receiving antihypertensive medication | NCF1 | 1.100 (1.057–1.145) | 3.23E-06 | 5.74E-03 | 60.047 |
HF in patients receiving antihypertensive medication | RELT | 0.697 (0.589–0.825) | 2.72E-05 | 4.82E-02 | 93.461 |