Proteome-wide mendelian randomization investigates potential associations in heart failure and its etiology: emphasis on PCSK9

Table 2 Mendelian randomization and colocalization analyses of circulating PCSK9 on HF in patients with CHD: Insights from the deCODE. dataset. HF: heart failure; CHD: Coronary heart disease; CI, Confidence interval; OR, Odds ratio

Outcome	Methods	OR (95% CI)	P value	Colocalization Analysis P_H4 (%)
HF in patients with CHD	IVW (P for heterogeneity = 0.560)	1.320 (1.226–1.421)	1.56E-13	99.993
	Weighted median	1.317 (1.213–1.429)	4.72E-11
	MR-Egger	1.273 (1.141–1.420)	0.023
	MR-Egger regression		0.445
	MR-PRESSO (no outliers detected)		0.613

ISSN: 1755-8794