Table 3 The distribution of affected alleles of SLC26A4 c.919-2A > G was found in patients with NSHL in nine different areas of Yunnan
Gene | Variant | Number of Affected Alleles | Total patients | Han Chinese group | Minority group | χ2 | P | OR (95%CI) |
|---|---|---|---|---|---|---|---|---|
(n = 1167) | (n = 533) | (n = 634) | ||||||
(frequencies) | (frequencies) | (frequencies) | ||||||
SLC26A4 | c.919-2A > G | Homozygous | 8 (0.69%) | 5 (0.94%) | 3 (0.47%) | 0.363 | 0.547 | 1.992 (0.474, 8.373) |
Heterozygous | 25 (2.14%) | 19 (3.56%) | 6 (0.95%) | 9.470 | 0.002 | 3.869 (1.534, 9.759) | ||
Total carrier rate | 33 (2.83%) | 24 (4.50%) | 9 (1.42%) | 10.018 | 0.002 | 3.274 (1.509, 7.107) | ||
Allele G | 41(1.76%) | 29(2.72%) | 12 (0.95%) | 10.562 | 0.001 | 2.927 (1.486, 5.765) | ||
c.2168 A > G | Homozygous | 1 (0.09%) | 0 (0.00%) | 1 (0.16%) | —— | 1.000 | —— | |
Heterozygous | 7 (0.60%) | 5 (0.94%) | 2 (0.32%) | 0.983 | 0.321 | 0.334(0.065, 1.729) | ||
Total carrier rate | 8 (0.69%) | 5 (0.94%) | 3 (0.47%) | 0.363 | 0.547 | 0.502(0.119, 2.111) | ||
Allele G | 9(0.40%) | 5 (0.47%) | 4 (0.32%) | 0.068 | 0.794 | 0.670(0.179, 2.510) |