Table 2 Association between MIAT polymorphisms and IS risk
From: lncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke
Polymorphisms | Controls, n = 310 | HEW, Pa | IS patients, n = 320 | HEW, Pb | OR (95%CI)† | P† | P(BH) |
|---|---|---|---|---|---|---|---|
rs2157598 | 0.831 | 0.642 | |||||
AA | 99 (31.9) | 112 (35.0) | 1.00(ref) | ||||
AT | 154 (49.7) | 158 (49.4) | 0.82 (0.53-1.26) | 0.370 | 0.663 | ||
TT | 57 (18.4) | 50 (15.6) | 1.07 (0.60-1.93) | 0.811 | 0.901 | ||
A | 352 (56.8) | 382 (59.7) | 1.00(ref) | ||||
T | 268 (43.2) | 258 (40.3) | 0.99 (0.75-1.31) | 0.954 | 0.954 | ||
Dominant model | |||||||
AA | 99 (31.9) | 112 (35.0) | 1.00(ref) | ||||
TT + TA | 211 (68.1) | 208 (65.0) | 0.88 (0.58-1.32) | 0.530 | 0.663 | ||
Recessive model | |||||||
AA + TA | 253 (81.6) | 270 (84.4) | 1.00(ref) | ||||
TT | 57 (18.4) | 50 (15.6) | 1.21 (0.71-2.04) | 0.484 | 0.663 | ||
rs5761664 | 0.798 | 0.824 | |||||
CC | 132 (42.6) | 146 (45.6) | 1.00(ref) | ||||
CT | 139 (44.8) | 139 (43.4) | 0.86 (0.57-1.31) | 0.488 | 0.663 | ||
TT | 39 (12.6) | 35 (10.9) | 1.55 (0.80-2.99) | 0.192 | 0.433 | ||
C | 403 (65.0) | 431 (67.3) | 1.00(ref) | ||||
T | 217 (35.0) | 209 (32.7) | 1.1 (0.82-1.47) | 0.515 | 0.663 | ||
Dominant model | |||||||
CC | 132 (42.6) | 146 (45.6) | 1.00(ref) | ||||
TT + TC | 178 (57.4) | 174 (54.4) | 0.97 (0.66-1.43) | 0.876 | 0.922 | ||
Recessive model | |||||||
CC + TC | 271 (87.4) | 285 (89.1) | 1.00(ref) | ||||
TT | 39 (12.6) | 35 (10.9) | 1.67 (0.90-3.12) | 0.106 | 0.303 | ||
rs1894720 | 0.711 | 0.143 | |||||
GG | 118 (38.1) | 133 (41.6) | 1.00(ref) | ||||
GT | 144 (46.5) | 137 (42.8) | 0.78 (0.51-1.19) | 0.250 | 0.500 | ||
TT | 48 (15.5) | 50 (15.6) | 1.48 (0.82-2.68) | 0.195 | 0.433 | ||
G | 380 (61.3) | 403 (63.0) | 1.00(ref) | ||||
T | 240 (38.7) | 237 (37.0) | 1.11 (0.83-1.47) | 0.490 | 0.663 | ||
Dominant model | |||||||
GG | 118 (38.1) | 133 (41.6) | 1.00(ref) | ||||
TT + GT | 192 (61.9) | 187 (58.4) | 0.91 (0.61-1.36) | 0.656 | 0.772 | ||
Recessive model | |||||||
GG + GT | 262 (84.5) | 270 (84.4) | 1.00(ref) | ||||
TT | 48 (15.5) | 50 (15.6) | 1.70 (0.98-2.93) | 0.058 | 0.232 | ||
rs9625066 | 0.732 | 0.354 | |||||
CC | 174 (56.1) | 202 (63.1) | 1.00 (ref) | ||||
CA | 118 (38.1) | 101 (31.6) | 0.55 (0.37-0.85) | 0.006 | 0.040 | ||
AA | 18 (5.80) | 17 (5.30) | 0.39 (0.16-0.94) | 0.036 | 0.180 | ||
C | 466 (75.2) | 505 (78.9) | 1.00 (ref) | ||||
A | 154 (24.8) | 135 (21.1) | 0.59 (0.42-0.82) | 0.002 | 0.020 | ||
Dominant model | |||||||
CC | 174 (56.1) | 202 (63.1) | 1.00 (ref) | ||||
AA + CA | 136 (43.9) | 118 (36.9) | 0.53 (0.35-0.80) | 0.002 | 0.020 | ||
Recessive model | |||||||
CC + CA | 292 (94.2) | 303 (94.7) | 1.00 (ref) | ||||
AA | 18 (5.80) | 17 (5.30) | 0.49 (0.21-1.16) | 0.106 | 0.303 | ||