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Fig. 4 | BMC Medical Genomics

Fig. 4

From: GPX8+ cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment

Fig. 4

GPX8 is associated with adverse clinical outcomes. K-M curves were analyzed for OS (A) and PFS (B) of GPX8 in 6 independent cohorts. C Heatmap of the distribution of GPX8 with clinicopathologic features. D Comparison plot of GPX8 with different clinical features. E Forest plot of multivariate cox analysis of GPX8 in combination with other clinicopathologic features. F Differential expression of GPX8 at mRNA level in normal and tumor tissues in the TCGA cohort. G Differences in protein expression levels of GPX8 in normal and tumor tissues were analyzed using the ULCAN database. H Mutation profile of GPX8 was analyzed using cBioportal database (***p < 0.001; **p < 0.01; *p < 0.05; ns. no significance)

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