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Fig. 5 | BMC Medical Genomics

Fig. 5

From: GPX8+ cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment

Fig. 5

Role of GPX8 in the tumor microenvironment. A Correlation scatter plot of GPX8 with tumor purity. B Correlation scatter plot of GPX8 with ESTIMATE score, immune score, and stromal score. C Heatmap of the distribution of 29 TME-associated signatures with GPX8 expression values. D Relationship between GPX8 expression and the proportion of 22 immune cells infiltrated. E Sankey diagram of TME attributes and immune subtype attributes of patients in different GPX8 groups. Distribution of GPX8 expression in TME subtypes defined by Bagaev et al. (F) and immune subtypes defined by Thorsson et al. (G). H Heatmap of different TME-related scores correlating with GPX8 (***p < 0.001; **p < 0.01; *p < 0.05; ns. no significance)

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BMC Medical Genomics

ISSN: 1755-8794

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