Table 3 Association between candidate SNPs in CYP4A22 and susceptibility to CHD.
From: Novel polymorphisms in CYP4A22 associated with susceptibility to coronary heart disease
SNP ID | Model | Genotype | Control (n = 481) | Case (n = 481) | Crude analysis | Adjusted analysis | ||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p-value a | OR (95% CI) | p-value b | |||||
rs76011927 | Allele | C | 900 (93.6%) | 901 (93.7%) | 1 | |||
T | 62 (6.4%) | 61 (6.3%) | 0.98 (0.68–1.42) | 0.926 | ||||
Codominant | CC | 422 (87.7%) | 422 (87.7%) | 1 | 1 | |||
CT | 56 (11.6%) | 57 (11.8%) | 1.02 (0.69–1.51) | 0.930 | 1.02 (0.69–1.51) | 0.922 | ||
TT | 3 (0.6%) | 2 (0.4%) | 0.67 (0.11–4.01) | 0.658 | 0.60 (0.10–3.64) | 0.578 | ||
Dominant | CC | 422 (87.7%) | 422 (87.7%) | 1 | 1 | |||
CT-TT | 59 (12.3%) | 59 (12.3%) | 1.00 (0.68–1.47) | 0.999 | 1.00 (0.68–1.47) | 0.990 | ||
Recessive | CC-CT | 478 (99.4%) | 479 (99.6%) | 1 | 1 | |||
TT | 3 (0.6%) | 2 (0.4%) | 0.67 (0.11-4.00) | 0.656 | 0.60 (0.10–3.62) | 0.570 | ||
Overdominant | CC-TT | 425 (88.4%) | 424 (88.2%) | 1 | 1 | |||
CT | 56 (11.6%) | 57 (11.8%) | 1.02 (0.69–1.51) | 0.920 | 1.02 (0.69–1.52) | 0.910 | ||
Log-additive | - | - | - | 0.98 (0.68–1.41) | 0.926 | 0.98 (0.68–1.40) | 0.900 | |
rs12564525 | Allele | T | 535 (55.6%) | 579 (60.2%) | 1 | |||
C | 427 (44.4%) | 383 (39.8%) | 0.83 (0.69–0.99) | 0.042 | ||||
Codominant | TT | 145 (30.1%) | 172 (35.8%) | 1 | 1 | |||
TC | 245 (50.9%) | 235 (48.9%) | 0.81 (0.61–1.08) | 0.143 | 0.82 (0.61–1.08) | 0.160 | ||
CC | 91 (18.9%) | 74 (15.4%) | 0.69 (0.47-1.00) | 0.050 | 0.68 (0.47-1.00) | 0.049 | ||
Dominant | TT | 145 (30.1%) | 172 (35.8%) | 1 | 1 | |||
TC-CC | 336 (69.8%) | 309 (64.2%) | 0.78 (0.59–1.02) | 0.064 | 0.78 (0.59–1.02) | 0.070 | ||
Recessive | TT-TC | 390 (81.1%) | 407 (84.6%) | 1 | 1 | |||
CC | 91 (18.9%) | 74 (15.4%) | 0.78 (0.56–1.09) | 0.147 | 0.77 (0.55–1.08) | 0.130 | ||
Overdominant | TT-CC | 236 (49.1%) | 246 (51.1%) | 1 | 1 | |||
TC | 245 (50.9%) | 235 (48.9%) | 0.92 (0.71–1.18) | 0.520 | 0.93 (0.72–1.20) | 0.560 | ||
Log-additive | - | - | - | 0.82 (0.69–0.99) | 0.040 | 0.82 (0.69–0.99) | 0.040 | |
rs2056900 | Allele | G | 501 (52.2%) | 455 (47.3%) | 1 | |||
A | 459 (47.8%) | 507 (52.7%) | 1.22 (1.02–1.46) | 0.032 | ||||
Codominant | GG | 125 (26%) | 110 (22.9%) | 1 | 1 | |||
AG | 251 (52.3%) | 235 (48.9%) | 1.06 (0.78–1.45) | 0.697 | 1.07 (0.78–1.47) | 0.661 | ||
AA | 104 (21.7%) | 136 (28.3%) | 1.49 (1.04–2.13) | 0.032 | 1.49 (1.04–2.14) | 0.032 | ||
Dominant | GG | 125 (26%) | 110 (22.9%) | 1 | 1 | |||
AG-AA | 355 (74%) | 371 (77.1%) | 1.19 (0.88–1.60) | 0.253 | 1.20 (0.89–1.61) | 0.240 | ||
Recessive | GG-AG | 376 (78.3%) | 345 (71.7%) | 1 | 1 | |||
AA | 104 (21.7%) | 136 (28.3%) | 1.43 (1.06–1.91) | 0.018 | 1.42 (1.06–1.91) | 0.020 | ||
Overdominant | GG-AA | 229 (47.7%) | 246 (51.1%) | 1 | ||||
AG | 251 (52.3%) | 235 (48.9%) | 0.88 (0.68–1.13) | 0.310 | ||||
Log-additive | - | - | - | 1.22 (1.02–1.46) | 0.031 | 1.22 (1.02–1.46) | 0.031 | |
rs4926581 | Allele | G | 500 (52.0%) | 462 (48.0%) | 1 | 1 | ||
T | 462 (48.0%) | 500 (52.0%) | 0.87 (0.68–1.12) | 0.290 | 1.17 (0.98–1.40) | 0.083 | ||
Codominant | GG | 122 (25.4%) | 109 (22.7%) | 1 | 1 | |||
GT | 256 (53.2%) | 244 (50.7%) | 1.07 (0.78–1.46) | 0.685 | 1.08 (0.79–1.47) | 0.642 | ||
TT | 103 (21.4%) | 128 (26.6%) | 1.39 (0.96–2.01) | 0.077 | 1.40 (0.97–2.02) | 0.076 | ||
Dominant | GG | 122 (25.4%) | 109 (22.7%) | 1 | 1 | |||
GT-TT | 359 (74.6%) | 372 (77.3%) | 1.16 (0.86–1.56) | 0.327 | 1.17 (0.87–1.57) | 0.300 | ||
Recessive | GG-GT | 378 (78.6%) | 353 (73.4%) | 1 | 1 | |||
TT | 103 (21.4%) | 128 (26.6%) | 1.33 (0.99–1.79) | 0.060 | 1.33 (0.98–1.79) | 0.063 | ||
Overdominant | GG-TT | 225 (46.8%) | 237 (49.3%) | 1 | 1 | |||
GT | 256 (53.2%) | 244 (50.7%) | 0.90 (0.70–1.17) | 0.440 | 0.91 (0.71–1.18) | 0.480 | ||
Log-additive | - | - | - | 1.18 (0.98–1.42) | 0.077 | 1.18 (0.98–1.42) | 0.075 | |