Fig. 2

Clustered heatmap of significantly altered KEGG pathways in PPROM affected amnion tissue. Heatmap of differentially expressed genes between PPROM affected and unaffected amnion tissue among significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways clustered by row and column means. The -log10(adjusted p-value) derived from differential expression analysis is illustrated by the Gene Score color bar. The false discovery rate (FDR)-corrected p-value derived from functional enrichment analysis using the DAVID Functional Annotation Tool is illustrated by the Enrichment Term Score color bar. The Log2FC color bar identifies sets of genes which are significantly up or downregulated. The significantly enriched KEGG pathways (FDR p-value < = 0.05) in which the differentially expressed genes are a member of are labeled on the lower axis