Table 4 Correlation between clinical features and number of genes lost considering (1) genes in NF1 deletion, (2) ‘genes in other non-DGV, non-inherited losses’, and (3) ‘genes in other gains’
Median of genes lost (range) | p-value1 | |||
|---|---|---|---|---|
Overall Severity of NF | Mild/moderate | N = 9 | 34 (26–372) | 0.9424 |
Severe | N = 12 | 33 (26–37) | ||
Plexiform neurofibromas | No | N = 7 | 33 (26–35) | 0.0882 |
Yes | N = 11 | 34 (26–372) | ||
Lisch Nodules | No | N = 4 | 34 (32–36) | 0.3820 |
Yes | N = 9 | 33 (27–37) | ||
Macrocephaly | No | N = 5 | 34 (32–36) | 0.4073 |
Yes | N = 9 | 33 (26–35) | ||
Learning Difficulties | No | N = 2 | 26 (26–26) | 0.0217 |
Yes | N = 15 | 33 (32–372) | ||
Scoliosis | No | N = 13 | 34 (26–53) | 0.3384 |
Yes | N = 5 | 33 (32–34) | ||
Other Malignancies | No | N = 16 | 34 (26–372) | 0.5636 |
Yes | N = 4 | 33 (32–37) | ||