Table 6 Correlation between clinical features and number of genes lost (excluding Patient 2 with deletion > 5.5 Mb) and considering genes in NF1 deletion + ‘genes in other non-DGV, non-inherited losses’
Median of genes lost (range) | p-value1 | |||
|---|---|---|---|---|
Overall Severity of NF | Mild/moderate | N = 9 | 33 (25–227) | 0.8820 |
Severe | N = 12 | 33 (26–37) | ||
Plexiform neurofibromas | No | N = 7 | 33 (26–34) | 0.0711 |
Yes | N = 11 | 33 (26–227) | ||
Lisch Nodules | No | N = 4 | 33.5 (32–36) | 0.5688 |
Yes | N = 9 | 33 (25–37) | ||
Macrocephaly | No | N = 5 | 33 (32–36) | 0.3359 |
Yes | N = 9 | 33 (26–34) | ||
Learning Difficulties | No | N = 2 | 26 (26–26) | 0.0152 |
Yes | N = 15 | 33 (32–227) | ||
Scoliosis | No | N = 13 | 33 (26–37) | 0.3979 |
Yes | N = 5 | 33 (32–33) | ||
Other Malignancies | No | N = 16 | 33 (26–227) | 0.8038 |
Yes | N = 4 | 33 (32–37) | ||