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Table 2 Risk factors for COVID-19 patients from the first affiliated hospital of Guangzhou medical university

From: Peripheral blood indicators and COVID-19: an observational and bidirectional Mendelian randomization study

Risk factors

Healthy individuals

COVID-19 patients

P

FDR

White blood cell count

6.63 (5.51,8.04)

5.95 (4.15,7.69)

0.002*

0.004142857*

Basophil count

0.03 (0.00,0.05)

0.02 (0.01,0.03)

 < 0.001*

0.002230769*

Monocyte cell count

0.50 (0.40, 0.60)

0.46 (0.34, 0.61)

0.595

0.651132075

Lymphocyte cell count

2.10 (1.74,2.50)

1.65 (1.10,2.10)

 < 0.001*

0.002230769*

Eosinophil cell count

0.12 (0.10,0.22)

0.08 (0.02,0.15)

 < 0.001*

0.002230769*

Neutrophil cell count

3.70 (2.90,4.60)

3.28 (2.30, 4.30)

 < 0.001*

0.002230769*

Red blood cell count

4.81 (4.38,5.21)

4.16 (3.59, 4.57)

 < 0.001*

0.002230769*

Hemoglobin concentration

143.00 (130.00,153.00)

133.00 (121.00,146.75)

 < 0.001*

0.002230769*

Hematocrit

0.42 (0.39,0.45)

0.39 (0.35,0.43)

 < 0.001*

0.002230769*

Mean corpuscular hemoglobin concentration

341.00 (332.00,349.00)

341.00 (336.00,346.00)

0.911

0.926982456

Mean corpuscular hemoglobin

30.10 (28.90,31.20)

29.80 (28.73,30.90)

0.095

0.134390244

Mean corpuscular volume

88.00 (84.40,90.85)

87.20 (84.40, 90.10)

0.104

0.14027907

Red cell distribution width

13.00 (12.60,13.60)

12.90 (12.50,13.50)

0.04*

0.064444444

Mean platelet volume

8.90 (8.10,9.73)

8.40 (7.80,9.20)

 < 0.001*

0.002230769*

Plateletcrit

0.22 (0.19,0.25)

0.20 (0.16,0.24)

 < 0.001*

0.002230769*

Platelet count

246.00 (209.00,287.50)

236.00 (183.25,296.25)

0.079

0.117487179

Platelet distribution width

16.40 (15.80,16.80)

16.60 (16.20,17.10)

 < 0.001*

0.002230769*

Prothrombin time

12.95 (12.50,13.60)

13.35 (13.00,13.90)

0.001*

0.002230769*

Activated partial thromboplastin time

35.50 (33.90,38.55)

37.45 (35.15,40.88)

0.004*

0.007483871*

Thrombin time

16.70 (16.35,17.45)

18.10 (17.10,19.50)

 < 0.001*

0.002230769*

Fibrinogen

3.05 (2.66,3.40)

4.64 (3.48, 5.81)

 < 0.001*

0.002230769*

D-dimer

236(172,804)

594.00(366.00,1309.00)

 < 0.001*

0.002230769*

Serum cystatin C

0.82 ± 0.14

1.33 ± 0.69

0.111

0.146318182

Serum creatinine

82.00 (70.18,92.43)

79.70 (67.70, 94.10)

0.467

0.531098039

Uric acid

381.40 (313.40,476.40)

319.10 (264.03,390.45)

 < 0.001*

0.002230769*

Urea nitrogen

5.00 (4.10,5.70)

4.50 (3.70,5.90)

0.008*

0.0145*

β2-microglobulin

1.69 (1.66,2.11)

2.25 (1.86,3.21)

0.114

0.146933333

Alkaline phosphatase

65.40 (53.40,79.10)

58.70 (49.15,70.70)

0.014*

0.023882353*

Alanine aminotransferase

20.80 (13.20,32.80)

19.10 (12.40,29.15)

0.077

0.117487179

Aspartate aminotransferase

22.50 (18.60,27.20)

22.30 (19.10,29.70)

0.299

0.361291667

Gamma glutamyltransferase

23.30 (14.90,39.83)

23.00 (15.75,43.30)

0.212

0.261617021

Albumin

44.10 (42.60,45.90)

43.40 (37.10,46.65)

 < 0.001*

0.002230769*

Total bilirubin

10.70 (8.80,13.70)

13.10 (10.40,17.10)

 < 0.001*

0.002230769*

Direct bilirubin

2.30 (1.70,3.10)

2.00 (1.70,2.70)

0.002*

0.004142857*

Total bile acid

4.30 (3.20,6.13)

3.15 (1.87,4.93)

 < 0.001*

0.002230769*

Total protein

75.60 (73.00,78.30)

76.00 (68,45,80.25)

0.573

0.639115385

Myoglobin levels

14.70 (11.50,21.00)

18.80 (14.30,28.40)

0.001*

0.002230769*

Troponin I

2.40 (1.60,3.60)

3.50 (2.50,6.15)

 < 0.001*

0.002230769*

Creatine Kinase

111.70 (79.60,153.70)

78.85 (53.43,115.23)

 < 0.001*

0.002230769*

creatine kinase isoenzymes

9.00 (7.00,12.00)

9.00 (7.00,11.00)

0.767

0.823814815

Lactate dehydrogenase

177.50 (152.80,199.55)

205.00 (185.20,248.48)

 < 0.001*

0.002230769*

Hydroxybutyrate Dehydrogenase

112.00 (96.65,128.90)

135.00 (121.00,152.00)

 < 0.001*

0.002230769*

Glucose

5.25 (4.93,5.68)

5.31 (4.89,6.21)

0.064

0.100324324

HDL cholesterol

1.24 (1.08,1.45)

1.13 (0.96,1.33)

 < 0.001*

0.002230769*

LDL cholesterol

3.41 (2.80,3.90)

3.37 (2.89,3.85)

0.986

0.986

Total cholesterol

5.33 (4.57,6.12)

5.04 (4.44,5.67)

0.014*

0.023882353*

Triglyceride

1.35 (0.90,2.14)

1.36 (0.98,2.05)

0.884

0.915571429

Apolipoprotein A

1.30 (1.16,1.50)

0.74 (0.58,1.06)

 < 0.001*

0.002230769*

Apolipoprotein B

0.90 ± 0.28

0.75 ± 0.35

0.45

0.522

Hemoglobin A1a

0.99 (0.89,1.10)

1.09 (0.90,1.33)

0.101

0.13947619

Hemoglobin A1b

0.94 (0.85,1.10)

1.10 (0.86,1.20)

0.156

0.196695652

Hemoglobin A1c

5.45 (5.14,5.80)

5.96 (5.43,7.55)

0.004*

0.007483871*

C-Reactive protein

0.32 (0.09,1.31)

0.68 (0.10,6.38)

 < 0.001*

0.002230769*

Serum amyloid protein

5.00 (5.00,6.21)

93.83 (26.62,127.22)

0.004*

0.007483871*

Complement C3

0.88 ± 0.18

0.99 ± 0.20

0.34

0.40244898

Complement C4

0.21 (0.15,0.27)

0.29 (0.23,0.34)

0.034*

0.056342857

Transferrin

2.29 ± 0.33

1.71 ± 0.28

0.815

0.859454545

Ceruloplasmin

0.31 ± 0.03

0.34 ± 0.08

0.085

0.12325

  1. Continuous variables with nonnormal data distribution are presented as medians (interquartile range)
  2. Normally distributed continuous variables are presented as means ± SDs
  3. *Significantly different between healthy individuals and COVID-19 patients (p < 0.05)