Table 1 A total of 10 hub genes screened by MCC, MNC and Degree methods, and showed the functions by literature search
Name | Express by bioinformatics analysis | Function |
|---|---|---|
CYP7A1 | down | Catalyze a rate-limiting step in cholesterol catabolism and bile acid biosynthesis [29]. |
LSS | down | Synthesize lanosterol in the key cyclization reaction of l cholesterol biosynthesis and associated with glutathione peroxidase activity (Gpx) levels [30]. |
SREBF1 | down | Regulate transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway [31]. |
FASN | down | Catalyze the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH [32]. |
CD44 | up | The Chi3l1/CD44 axis as a critical pathway mediating APAP-induced hepatic platelet recruitment and tissue injury [33]. |
SPP1 | up | Characterize bile duct–associated macrophages and correlates with liver fibrosis severity [35, 36]. |
ITGAV | up | Play a central role in the progression of liver fibrosis as a known profibrogenic cytokine [38]. |
ANXA5 | up | Regulate hepatic macrophage polarization [34]. |
LGALS3 | up | Act as a mediator of acute inflammatory responses, including neutrophil activation and adhesion, monocyte macrophage hemoattraction, etc. [37]. |
PDGFRA | up | Play an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis [39]. |