Table 1 Demographic data of the allopurinol-induced cutaneous adverse drug reactions (cADRs)

Sex, n (%)

 Female

29 (51)

78 (77)

< 0.001

 Male

28 (49)

23 (23)

Age (years)

 Mean

66

62

0.087

 Median

69

64

Phenotype, n (%)

 SJS-TEN

25 (43.9)

-

 DRESS

24 (42.1)

-

 MPE

8 (14.0)

-

Allopurinol exposure

 Duration used (days)

21

776

< 0.001

Dose/day (mg)

 Mean (average ± SD)

159 ± 109

158 ± 105

0.992

 Median (range)

100

100

Laboratory result (mean ± SD)

 BUN, mg/dl

48 ± 32

22 ± 8

< 0.001

 Creatinine, mg/dl

1.96 ± 1.43

1.72 ± 1.22

0.174

 AST, U/L

99 ± 129

30 ± 20

< 0.001

 ALT, U/L

123 ± 152

37 ± 25

< 0.001

Underlying disease, n (%)

 Hypertension

27 (47.4)

60 (59.4)

0.878

 Chronic kidney disease

18 (31.6)

33 (32.7)

0.361

 Diabetes

13 (22.8)

13 (12.9)

0.017

 Dyslipidemia

4 (7.0)

16 (15.8)

0.017

 Cancer

0

6 (5.9)

-

Co-medication, n (%)

 Colchicine

20 (35.1)

52 (51.5)

0.469

 Prednisolone

2 (3.5)

9 (8.9)

0.354

 Simvastatin

5 (8.8)

16 (15.8)

0.659

 Sodium bicarbonate

3 (5.3)

16 (15.8)

0.134