Table 4 The association between the combined SNPs and allopurinol-induced cADRs vs. the tolerant controls
HLA/SNPs allele | cADRs vs. tolerant control | SJS-TEN vs. tolerant control | DRESS vs. tolerant control | MPE vs. tolerant control | ||||
|---|---|---|---|---|---|---|---|---|
Odds ratio (95%CI) | P-value | Odds ratio (95%CI) | P-value | Odds ratio (95%CI) | P-value | Odds ratio (95%CI) | P-value | |
HLA-B*58:01 | 137.2 (38.3–670.5) | 1.7 × 10− 27 | 582.0 (62.2–5447.3) | 3.7 × 10− 23 | 92.2 (22.6–375.1) | 2.3 × 10− 14 | 63.7 (8.4–829.2) | 2.7 × 10− 6 |
rs3099844, C > A rs9263726,G > A | 53.1 (18.9–170.3) | 2.2 × 10− 22 | 200.9 (27.6–8484.4) | 7.5 × 10− 17 | 42.9 (11.5–208.9) | 3.0 × 10− 12 | 3.4 (0.5–17.3) | 1.1 × 10− 1 |
rs3099844, C > A rs9263726,G > A rs9263733, C > T | 73.2 (24.2–266.8) | 1.9 × 10− 24 | 200.9 (27.6–8484.4) | 7.5 × 10− 17 | 42.9 (11.5–208.9) | 3.0 × 10− 12 | 14.5 (2.4 -107.6) | 1.1 × 10− 3 |
rs3099844, C > A rs9263726,G > A rs9263733, C > T rs9263745, G > A | 73.2 (24.2–266.8) | 1.9 × 10− 24 | 200.9 (27.6–8484.4) | 7.5 × 10− 17 | 42.9 (11.5–208.9) | 3.0 × 10− 12 | 25.7 (3.9–291.3) | 9.3 × 10− 5 |
rs3099844, C > A rs9263726,G > A rs9263733, C > T rs9263745, G > A rs4084090, A > G | 56.9 (18.9–214.6) | 3.4 × 10− 22 | 129.9 (18.6–5505.9) | 1.4 × 10− 14 | 38.3 (9.8–224.8) | 2.0 × 10− 11 | 16.4 (2.6–181.7) | 5.7 × 10− 4 |