Fig. 4
From: A novel COL4A5 splicing mutation causes alport syndrome in a Chinese family
Analysis of COL4A5 mutation. (A) Evolutionary conservation of amino acid residues altered by p.(P1432_G1433insEI) across different species. NCBI accession numbers are Homo sapiens: NP_000486.1; Danio rerio: XP_021333076.1; Equus caballus: XP_005614463.1; Macaca mulatta: XP_014983488.2; Mus musculus: XP_006528759.1; Pan troglodytes: XP_016798385.2; Papio Anubis: XP_031516835.1. Asterisk (*) means Inserted amino acids. (B) Prediction of the change in the three-dimensional (3D) structure of hydrogen bond by COL4A5 p.( P1432_G1433insEI) variant. (C) Prediction of the change in the three-dimensional (3D) structure of surface electrostatic potential by COL4A5 p.( P1432_G1433insEI) variant